摘要
目的通过对12例慢性铍病患者6年的随访,观察其肺功能的改变。方法选择12例明确诊断为慢性铍病的男性患者,平均年龄为(52±11)岁,进行各项呼吸功能指标的测定。此后每两年随访1次,共随访6年。结果与初次就诊时比较,随访6年中的用力肺活量、第一秒用力呼气容积、第一秒用力呼气容积与用力肺活量百分比、最大通气量、肺活量、肺一氧化碳弥散量、每升肺泡容积肺一氧化碳弥散量和动脉血氧分压均逐年下降,6年后分别降低27．0％、34．5%、18．1%、19．9％、30．7％、37．1%、37．0％和15．5%;残气量、残气量与肺总量百分比、动脉血二氧化碳分压和肺泡气-动脉血氧分压差逐年上升,6年后分别增高88．9％,39.8%、32．4％和43．6%。结论氧化铍明显影响肺功能,尤其是损害肺换气功能。
Objective To study the long-term changes of pulmonary function in 12 patients with chronic beryllium disease（CBD）. Methods Twelve male CBD patients, with a median age of （52 ±11） years, were included in this study. Pulmonary function tests were performed every 2 years in patients; the parameters included： forced vital capacity（FVC）, forced expiratory volume in one second （FEV1）, FVC/FEV1%, maximal ventilatory volume （MVV）, vital capacity （VC）, residual volume （RV）, total lung capacity （TLC）, RV/TLC%, diffusion capacity for carbon dioxide of lung （DLCO）, DLCO/alveolar volume （DLCO/VA）, partial pressure of oxygen （PaO2）, and partial pressure of carbon dioxide in arterial blood （PaCO2） ; and alveolar-artery oxygen gradient [P（A-a）O2 ]. Results FVC, FEV1, FEV1/FVC, MVV, VC, DLCO, DLCO/VA, and PaO2 were decreased significantly in all patients. Whereas RV, RV/TLC%, PaCO2 , and P（A-a）O2 were increased significantly. At 6 years of follow-up, FVC, FEV1 , FEV1/FVC% decreased by 27. 0%, 34. 5%, 18. 1%, respectively; and DL.CO decreased by 37. 1%. Conclusion The pulmonary function in CBD patients is obviously damaged by beryllium intoxication, especially for the function of gas exchange. （Shanghai Med J, 2007, 30：326-328）
出处
《上海医学》
CAS
CSCD
北大核心
2007年第5期326-328,共3页
Shanghai Medical Journal
关键词
慢性铍病
呼吸功能试验
随访观察
Chronic beryllium disease
Pulmonary function test
Follow-up observation
