期刊文献+

Bcl-2基因与良性前列腺增生 被引量:6

B-cell Lymphoma/Leukemia-2 and Benign Prostatic Hyperplasia
下载PDF
导出
摘要 B淋巴细胞瘤2(Bcl-2)基因是Bcl-2基因家族的一个重要成员。Bcl-2家族是在细胞凋亡过程中起重要作用的一类蛋白质。Bcl-2基因不改变细胞增殖速度,而是通过抵抗多种形式的细胞死亡延长细胞寿命,导致细胞数目增加。近年来越来越多的证据表明,Bcl-2基因与BPH的发生、发展密切相关。BPH的发病机理至今尚未完全阐明,随着研究的深入,细胞凋亡在其中的作用日益受到重视。本文从Bcl-2基因的抗凋亡机制和其与BPH的关系两方面,就近年来对其研究的最新进展进行综述,以探讨抗凋亡基因Bcl-2在BPH的发生、发展过程中所起的作用。 The B-cell lymphoma/leukemia-2 (Bcl-2) gene is an important member of the Bcl-2 family, a type of protein that plays an important role in the process of cell apoptosis. Bcl-2 does not change the rate of cell proliferation, but prolongs the life and increases the number of cells by counteracting a series of apoptosis. In the recent years, more and more evidence has shown a close correlation of the Bcl-2 gene with the development and progression of benign prostatic hyperplasia ( BPH ) , a disease whose mechanism is not yet fully understood but is drawing more and more attention towards the role of cell apoptosis.
出处 《中华男科学杂志》 CAS CSCD 北大核心 2009年第5期452-454,共3页 National Journal of Andrology
基金 黑龙江省普通高等学校骨干教师创新能力资助计划(1055G044)~~
关键词 BCL-2基因 细胞凋亡 良性前列腺增生 Bcl-2 gene apoptosis benign prostatic hyperplasia
  • 相关文献

参考文献18

  • 1季红斌,翟琦巍,刘新垣,郑仲承.bcl-2基因的转录调控[J].生物化学与生物物理学报,2000,32(2):95-99. 被引量:35
  • 2Cao X, Rodarte C, Zhang L, et al. Bcl2/bc1-xl inhibitor engenders apoptosis and increases chemosensitivity in mesothelioma. Cancer Biol Ther, 2007, 6 (2) : 246-252. 被引量:1
  • 3Moller C, KarlbergM, Abrink M, et al. B cl-2 and Bcl-xl are indispensable for the late phase of mast cell development from mouse embryonic stem cells. Exp Hematol, 2007, 35(3) : 385- 393. 被引量:1
  • 4Staecker H, Liu W, Malgrange B, et al. Vector-mediated delivery of bcl-2 prevents degeneration of auditory hair ceils and neurons after injury. ORL J Otorhinolaryngol Relat Spec, 2007, 69( 1 ) : 43-50. 被引量:1
  • 5Amarnath D, Li X, Kato Y, et al. Gene expression in individual bovine somatic cell cloned embryos at the 8-cell and blastocyst stages of preimplantation development. J Reprod Dev, 2007, 53 (6) : 1247-1263. 被引量:1
  • 6Gareskog M, Cederberg J, Eriksson U J, et al. Maternal diabetes in vivo and high glucose concentration in vitro increases apoptosis in rat embryos. Reprod Toxicol, 2007, 23 ( 1 ) : 63-74. 被引量:1
  • 7Boelhauve M, Sinowatz F, Wolf E, et al. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biol Reprod, 2005, 73(4) : 737-744. 被引量:1
  • 8Eom TY, Roth KA, Jope RS. Neural precursor cells are protected from apoptosis induced by tropbic factor withdrawal or genotoxic stress by inhibitors of glycogen synthase kinase 3. J Biol Chem, 2007, 282(31): 22856-22864. 被引量:1
  • 9Monniaux D. Oocyte apoptosis and evolutiou of ovarian reserve. Gynecol Obstet Fertil, 2002, 30(10) : 822-826. 被引量:1
  • 10Cho HJ, Kim JK, Kim KD, et al. Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells. Cancer Lett, 2006, 237 ( 1 ) : 56- 66. 被引量:1

二级参考文献16

共引文献58

同被引文献101

引证文献6

二级引证文献101

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部