摘要
目的评价3种用药方案根除幽门螺杆菌(Hp)的成本-效果。方法将120例Hp阳性消化性溃疡患者随机分为OAC、OAF、OAM等3组,每组40例。OAC组采用洛赛克、阿莫西林、克拉霉素三联疗法,OAF组采用洛赛克、阿莫西林、呋喃唑酮三联疗法,OAM组采用洛赛克、阿莫西林、甲硝唑三联疗法,均为口服,1日2次,疗程7d。运用药物经济学成本-效果分析方法进行评价。结果OAC组HP根除率最高,明显高于OAM组,P<0.05。OAF组C/E最佳。OAF组△C/△E也较为理想,对比于OAM组仅为0.4。OAC组不良反应最少,明显优于OAM组,P<0.05。结论OAC方案Hp根除率最高,但费用也较高,经济条件许可者可选用。OAF方案具有较好的Hp根除率,不良反应较少,而且成本-效果比最佳,值得推广使用。
OBJECTIVE To evaluate the cost-effectiveness of three therapeutic shemes for the eradication of Helicobacter pylori.METHODS 120 cases with Helicobacter pylori infection were randomly divided into 3 groups, OAC, OAF and OAM group, 40 cases in each group. Patients in OAC group were treated with omeprazole, Amoxicillin and clarithromycin. Patients in OAF group were treated with omeprazole, Amoxicillin and furazolidone. Patients in OAM group were treated with omeprazole, Amoxieillin and metronidazole. All treatment schemes were twice one day, seven day a period. The data was evaluated with cost-effectiveness analysis. RESULTS The eradication of rate Hp in OAC group was the most highest, and was superior to OAM group, P 〈 0.05. C/E of OAF group was the best. △C/△E of OAF group was good too, it was only 0.4 contrast with OAM group.The side effect of OAC group was superior to OAM group, P 〈 0.05. CONCLUSION The eradication rate of Hp in OAC group was the most highest, but OAC schemes cost more, so it can be used if money permit. The eradication rate of Hp in OAF group was good, and less side effect, and its E/C was the best, so OAF schemes w^s worth to be popularized.
出处
《海峡药学》
2009年第5期99-101,共3页
Strait Pharmaceutical Journal
关键词
成本-效果分析
幽门螺杆菌
克拉霉素
Cost-effectiveness analysis
Helieobacter pylori
Clarithromycin
