摘要
目的：对以埃索美拉唑和奥美拉唑为基础疗程为1周的三联/四联疗法根除幽门螺杆菌的疗效进行系统评价。方法：检索Pubmed、Embase数据库、Cochrane图书馆临床对照试验资料库、中国知网、维普数据库和万方数据库,检索时限从建库至2013年10月,搜集公开发表的有关埃索美拉唑与奥美拉唑对比治疗幽门螺杆菌感染的随机对照临床试验。应用Rev Man 5.2软件对符合条件的纳入研究进行Meta分析。结果：共5项研究符合入选标准。Meta分析结果表明,与奥美拉唑相比,埃索美拉唑与适当的抗菌疗法联合用药根除幽门螺杆菌疗效更好（OR=2.59,95%可信区间：1.27~5.29,P=0.009）。埃索美拉唑与奥美拉唑治疗引发的不良反应发生率比较差异无统计学意义（OR=1.23,95%可信区间：0.72~2.09,P=0.45）。结论：埃索美拉唑较奥美拉唑根除幽门螺杆菌感染效果更好,但尚需进一步在前瞻性随机对照临床试验中加以验证。
OBJECTIVE ：To conduct a systematic analysis on the efficacy of esomeprazole vs. omeprazole （three- drug/four-drug combination therapy at a basic course of treatment of one week for Helicobacter pylori infection. METHODS： The published randomized controlled trials （RCTS） （until October 2013） comparing the efficacy between esomeprazole and omeprazole in the treatment of Helicobacter pylori infection were searched in Pubmed, Embase, the Cochrane Library, CNKI, VIP and Wanfang Data. The Meta-analyses was performed by using RevMan 5.2 software. RESULTS： A total of 5 RCTs involving 356 patients were included. The meta-analysis showed that esomeprazole was more effective than omeprazole when used concurrently with other antibiotics in H. pylori eradication （M-H = 2. 59, 95% CI： 1.27-5.29, P = 0. 009）. There were no significant differences between two groups in the incidence of adverse effects （M-H = 1.23, 95% CI： 0.72-2.09, P = 0.45）. CONCLUSIONS： Esomeprazole is more effective than omeprazole in H. pylori eradication rate; however, this result needs to be further verified in prospective RCTs.
出处
《中国医院用药评价与分析》
2015年第2期180-183,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家科技支撑计划子课题(No.2013BAI06B04Y023103)
