摘要
目的研究室间隔缺损(VSD)患儿术前术后血浆心钠素(ANP)表达水平的变化。方法选择40例室间隔缺损患儿(n=40),根据其缺损大小分为3组,分别在术前、术后第1、2、3、5天抽取静脉血,采用特异性放射免疫分析方法检测其血浆ANP的表达,同时检测30例无心肺疾患健康儿童的血浆心钠素含量做为对照。结果①实验组血浆ANP表达水平高于对照组(P<0.05);②不同缺损大小的VSD患儿其血浆ANP表达水平不一样,缺损越大,其表达水平越高,相互间对比差异有统计学意义(P<0.05);③三组VSD患儿术后第5天其血浆ANP表达均有下降,与术前相比差异具有统计学意义(P<0.05)。结论VSD患儿血浆ANP表达水平明显高于对照组,且与缺损大小有关。
Objective To investigate the clinical significance of the changes in plasma atrial natriuretic peptide （ANP） in children with ventricular septal defect （VSD）. Methods 40 children with VSD were collected, and they were divided into three groups according to defect range, plasma ANP levels were measured by specific radioimmunoassary before and after cardiopulmonary bypass 1, 2, 3 and 5 days. And 30 children were taken as control group. Results The plasma levels of ANP were significantly increased in the patient groups as compared with that of the control group （ P 〈 0.05 ） ; There was significant differences in plasma levels of the ANP according to defect range （P 〈 0.05） ; The plasma ANP were decreased after operation fifth days compared with that before operation in three groups of ventricular septal defect （P 〈 0.05）. Conclusion The plasma ANP levels are increased in the children with ventricular septal defect, which suggests that ANP play important roles in the pathophysiological processes of ventricular septal defect in children.
出处
《宁夏医学杂志》
CAS
2009年第5期404-405,共2页
Ningxia Medical Journal
基金
宁夏回族自治区自然科学基金(编号:NZ07104)
关键词
心钠素
室间隔缺损
放射免疫法
体外循环
Atrial natriuretic peptide
Ventricular septal defect
Radio - immunoassary
Cardiopulmonary bypass
