摘要
通过对左向右分流型先天性心脏病（先心病）手术前后血浆心钠素（ｐＡＮＰ）浓度的研究，发现先心病血浆心钠素浓度与正常对照组比较有显著性差异，术后４８ｈ，ｐＡＮＰ浓度进一步升高，１０～１４ｄ有下降趋势，但与正常对照组比较仍有显著性差异；术后２月，ｐＡＮＰ浓度恢复正常。这表明：左向右分流型先心病患儿在术后一段时间内，血液动力学、扩大的心房及心功能仍不能完全恢复正常。术后４８ｈ，ｐＡＮＰ浓度的进一步升高，可能与心肌细胞的损伤、急性容量的扩张有关。然室间隔缺损术后并发症者，ｐＡＮＰ浓度显著、持续升高。我们推测，ｐＡＮＰ浓度可能作为评价先心病手术疗效的一种有价值的生化指标，应予进一步探讨。
Plasma atrial natriuretic polypeptide(ANP)was measured in 25 children with congenital heart disease with left to right shunt flow.Their plasma ANP concentration further increased during the 48 hours after the operation and decreased from the 10th to l4th.days postoperatively but was still obviously higher than that of the control group.However,there was no significant difference 2 months later.2 patients with postopertion complications had a lasting and significantly higher plasma ANP concentration.We estimated that plasma ANP concentration might be valuable for the evaluation of operative curative effect.
关键词
先天性心脏病
血浆
心钠素
儿童
myocardium/SE
peptides/BL
heart defects,congenital/BL
heart surgery
