摘要
目的:探讨在体外受精一胚胎移植(IVF-ET)过程中延长促性腺激素(Gn)使用时间对卵巢低反应者的影响。方法:回顾性分析本中心自2005年1月～2006年12月行IVF-ET治疗的患者922例,根据卵巢低反应的预测标准选择促排卵治疗方案,经预测排除卵巢低反应者选择长方案806例,经预测可能发生卵巢低反应者选择短方案116例(C组)。在促排卵过程中,经预测排除卵巢低反应者选择长方案806例中仍有149例患者发生了无法预测的卵巢低反应(B组),未发生卵巢低反应者657例(A组),比较3组之间的年龄、基础FSH、E2、Gn使用时间、Gn使用量、胚胎种植率、临床妊娠率。结果:A组与B组之间在年龄、基础FSH、E2、胚胎种植率(20.8%vs20.1%)、临床妊娠率(34.3%vs31.9%)之间差异无显著性(P>0.01),而在Gn使用量[(35.09±8.96)支vs(52.97±15.93)支]、Gn使用时间[(11.52±1.18)天vs(15.34±3.56)天]、获卵数之间差异有显著性(P<0.01)。B组与C组相比较Gn使用量[(52.97±15.93)支vs(38.13±16.14)支]、Gn使用时间[(15.34±3.56)天vs(9.78±2.60)天]之间差异有显著性(P<0.01),两组妊娠率(31.9%vs21.6%)有差异。结论:在IVF-ET治疗过程中,对无法预测的卵巢低反应者,采用延长Gn使用时间可以增加获卵数,降低周期取消率,改善IVF结局。
3 Objective ： To explore the effect of prolonging administration gonadotropin on ovarian poor responder in in vitro fertilization and embryo transfer （ IVF - ET） . Methods ： The clinical data of 922 cases undergoing IVF - ET from January 2005 to December 2006 were analysed retrospectively, according to the predictive criterion of ovarian poor response, 116 cases predicted as poor response received the short protocol （C group） ; the others received the long protocol. Among the latter, there were 149 cases undergoing unexpectedly ovarian poor response （B group） and 657 cases were normal ovarian response （A group） . The age, the basic levels of FSH and E2 in serum, the doses of gonadotrophin, the during of administration, implantation rate of embryo and clinic pregnancy rate were recorded. Results ： There was no significant difference in age, basic levels of FSH and E2 in serum, implantation rate of embryo （20. 8% vs 20. 1% ） and clinic pregnancy rate （34. 3% vs 31.9% ） between A group and B group （P 〉0. 01 ）, while there were significant difference in the doses of gonadotrophin [ （35.09 ±8.96） bottles vs （52. 97 ± 15.93） bottles] and the duration of administration [ （ 15.34 ±3.56） days vs （9.78 ±2. 60） days ] （ P 〈 0. 01 ） and the number of oocytes per retrieval between A group and B group. There was significant difference in the doses of gonadotrophin [ （52. 97 ± 15.93） bottles vs （38.13 ± 16. 14） bottles] , the during of adminstration [（ 15.34 ±3.56 ） days vs （9. 78 -2. 60） days] and clinical pregnancy rate （31.9% vs 21.6% ） between B group and C group （P 〈0. 01 ） . Conclusion： In the therapy of IVF - ET, prolonging to administration administration of gonadotropin on poor ovarian responders can inerease the number of oocytes per retrieval, decrease cancellation rate of cycle, improve IVF outcomes.
出处
《中国妇幼保健》
CAS
北大核心
2009年第15期2135-2138,共4页
Maternal and Child Health Care of China
关键词
卵巢低反应
IVF—ET
促性腺激素
妊娠
Poor ovarian response
In vitro fertilization and embryo transfer
Gonadotropin
Pregnancy
