摘要
脂联素与脂联素受体结合，经多种信号转导途径发挥改善胰岛素抵抗、调节糖脂代谢、负性调控炎性反应以及拮抗动脉粥样硬化的作用。一些病理生理过程中脂联素水平升高，但没有显著保护性效应，提示存在脂联素抵抗。脂联素抵抗的机制包括脂联素聚合能力改变、脂联素受体（AdipoRs）表达减少及脂联素受体后AMP活化蛋白激酶（AMPK）、过氧化物酶体增殖物活化受体（PPAR）α等信号通路转导障碍。高血糖、肥胖、胰岛素抵抗等与脂联素抵抗密切相关，可以互为因果，形成恶性循环。
Adiponectin can improve insulin sensitivity,glucose and lipid metabolism and exert anti- inflammatory and antiatherogenic effects by binding to its receptors, leading to activation of some signaling pathways. Hyperadiponectinaemia is found in some pathophysiological processes ,without significant protective effect, which indicates the existence of adiponectin resistance. Mechanism of adiponectin resistance may include impaired muhimerization of adiponectin mutants, down regulation of adiponectin receptors （ AdipoRs ） expression and deterioration of postreceptor signaling via AMP activated protein kinase （AMPK） and peroxi- some proliferator activated receptor （PPAR）et activation. Hyperglycemia, obesity, and insulin resistance are closely related to adiponectin resistance. They may be a reciprocal causation and form a vicious circle.
出处
《国际内分泌代谢杂志》
2009年第3期211-213,216,共4页
International Journal of Endocrinology and Metabolism
关键词
脂联素
受体
信号转导
脂联素抵抗
Adiponectin
Receptor
Signal transduction
Adiponectin resistance
