摘要
目的通过对婴幼儿泌尿系统结石的成分分析，探讨结石成因，以利于预防和治疗。方法收集婴幼儿泌尿系统结石标本16例，均有同一品牌问题奶粉喂养史。结石组分用高效液相色谱分离制备，电喷雾质谱、电子轰击质谱和傅里叶变换红外光谱进行结构鉴定，并用高效液相色谱对结石中的主要组分进行定量测定。结果通过分离和组分结构鉴定及定量测定，结石中的主要组分为三聚氰胺和尿酸，尿酸和三聚氰胺的比例约为2：1（摩尔比）。结石中尿酸平均含量为（53．9±11．7）％，三聚氰胺为（23．2±5．7）％。结论因食用问题奶粉而导致婴幼儿泌尿系统结石的主要原因是三聚氰胺与尿酸形成了不溶性盐而导致结石形成。
Objective To identify the main compositions of urinary calculi found in pediatric patients who had the history of exposing to infant formula milk powder contaminated with melamine and try to find out the urinary calculus formation mechanism in these patients. Methods Sixteen patients were studied. These infant patients with urinary calculi due to consumption of melamine tainted milk powder had been admitted to hospital from June, 2008 to August, 2008. The components of the urinary calculi were separated by liquid chromatograph, and identified by electrospray ionization mass spectrometry, electron bombard ionization mass spectrometry, Fourier transform infrared spectroscopy, and quantitatively determined by liquid chromatograph. Results The main chemical components of the urinary calculi were melamine and uric acid. The molar ratio of uric acid to melamine was 2 ： 1. Conclusion The main urinary calculus formation mechanism in infant patients who exposed to the infant formula milk powder contaminated with melamine is melamine and uric acid formed indissoluble complex.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2009年第3期188-190,共3页
Chinese Journal of Urology
关键词
尿路结石
婴儿
三聚氰胺
尿酸
成分分析
Urinary calculi
Infants
Melamine
Uric acid
Composition analysis
