摘要
目的：为研究抗着丝点抗体（ＡＣＡ）与临床疾病的关系。方法：回顾性总结了７１例ＡＣＡ阳性患者的临床资料。结果：ＡＣＡ可在多种疾病中出现，其中系统性硬化症３０例（４２２％），干燥综合征１０例（１４１％），系统性红斑狼疮６例（８５％），类风湿关节炎５例（７％），局限型硬皮病５例（７％），仅有雷诺现象但诊断不清者４例（５６％），ＣＲＥＳＴ综合征、重叠综合征、不明原因肝硬化、闭塞性脉管炎各２例（２８％），原发性胆汁性肝硬化、硬化性胆管炎、黄褐斑合并白癜风各１例（１４％）。结论：ＡＣＡ相关的临床症状为雷诺现象（５７７％）和皮肤硬化（５３５％）。ＡＣＡ并非ＣＲＥＳＴ综合征的特异性抗体。
Objective:To study the association of anticentromere antibodies (ACA) with various diseases.Methods:A total of 71 patients with positive ACA were retrospected.Results:There were 30 patients with systemic sclerosis (422%),10 with Sjogren′s syndrome(141%),6 with systemic lupus erythematosus (85%),5 with rheumatoid arthritis and localized sclerosis (70%) respectively,4 with only Raynaud′s phenomenon without any definite diagnosis (56%),2 with CREST syndrome,overlap syndrome,cirrhosis of unknown causes and buerger′s disease (28%) respectively,and 1 with primary billiary cirrhosis,sclerous cholangitis,and chloasmavitiligo (14%) respectively.Conclusion:The major clinical characteristics of the patients correlated with ACA are Raynaud′s phenomenon (577%) and scleroderma(535%).ACA are not specific for CREST syndrome.
出处
《中华风湿病学杂志》
CAS
CSCD
1998年第1期17-20,共4页
Chinese Journal of Rheumatology
