摘要
目的:研究血清胱抑素C(CysC)与冠心病的相关性。方法:回顾性分析525例高度怀疑冠心病而行冠脉造影患者的临床资料,从冠心病病情程度、冠脉病变支数和冠脉病变Gensini总积分3方面研究血清CysC水平与冠心病之间的关系。应用免疫比浊法检测血清CysC浓度,对CysC水平与冠心病病情、冠脉病变程度和冠脉病变Gensini总积分进行单因素和多因分析。结果:①随着血清CysC水平的升高,冠心病患者病情逐渐加重,冠脉病变支数和Gensini总积分增加;在急性心梗时由于急性时相反应血清CysC水平出现下降;②Logistic回归结果显示CysC与冠脉有无病变显著相关(OR值5.346,95%CI为2.225～12.846,P<0.01);③多元逐步回归结果显示在校正了年龄、性别等因素之后,CysC与冠脉病变Gensini总积分(β=0.149,P<0.01)仍然独立相关。结论:血清CysC水平与冠心病有密切关系。随着血清CysC水平升高,冠心病患者病情逐渐加重,冠脉病变程度也更加严重。
Objective：To investigate the relationship between serum levels of cystatin C and severity of coronary heart disease （CHD）. Methods：Five hundred and twenty-five patients with CHD who underwent coronary angiography were selected in the study. The relationship between serum levels of cystatin C and the pathogenetic condition of CHD,the number of diseased vessels and the CHD Gensini cumulative index was evaluated. Serum levels of cystatin C was measured by nephelometric immunoassay. All data were analyzed by univariate and multivariate analyses. Results： （1）With the increase of serum levels of cystatin C,the pathogenetic condition in patients with CHD became more serious,the number of diseased vessels and the CHD Gensini cumulative index increased.Due to the reaction at the acute phase of acute myocardial infarction （AMI）, the serum levels of cystatin C decreased;（2）Further logistic regression analysis indicated that cystatin C had significant correlation with pathological changes of coronary artery（OR was 5.346,95% CI = 2.225- 12.846, P 〈 0.01 ） ; （3）After adjusting the influencing factors such as age, sex and so on, multivariable stepwise regression analysis showed that cystatin C also had significant correlation with the CHD Gensini cumulative index （β = 0.149,P 〈 0.01）. Conclusion：The serum levels of cystatin C had significant correlations with CHD.With the increase of serum levels of cystatin C,the pathogenetic condition and pathological changes of coronary artery in patients with CHD became more and more serious.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2009年第5期702-706,731,共6页
Journal of Nanjing Medical University(Natural Sciences)
