摘要
目的:了解短程化疗方案每日用药和全程间歇短程化疗方案对初治涂阳肺结核空洞病例的近期疗效。方法:2HRZE/4HR方案,随机选择初治涂阳肺结核患者81例,A组(治疗组)肺结核空洞病例40例,B组(对照组):肺结核无空洞病例41例。2H3R3Z3E3/4H3R3方案,随机选择初治涂阳肺结核患者82例,C组(治疗组)肺结核空洞病例41例,D组(对照组):肺结核无空洞病例41例。两组患者年龄、性别构成差异无显著性。结果:2HRZE/4HR方案,A组化疗2、3个月末痰菌阴转率分别为92.5%和95.0%,B组阴转率分别为95.1%和97.6%,差异无统计学意义(P=0.65、0.55)。治愈77例,治愈率95.1%,其中,A组治愈率92.5%,B组治愈率97.6%,差异无统计学意义(P=0.30)。2H3R3Z3E3/4H3R3方案,C组化疗2、3个月末痰菌阴转率分别为82.9%和87.8%,D组阴转率均为95.1%,差异无统计学意义(P=0.08,0.075)。治愈69例,治愈率84.1%,其中,C组治愈率75.6%,D组治愈率92.7%,差异有统计学意义(P=0.03)。比较两种化疗方案的总治愈率和对肺结核空洞病例治愈率,均以2HRZE/4HR方案为优(P=0.02,0.03),对肺结核无空洞病例治愈率差异无统计学意义(P=0.30)。结论:2H3R3Z3E3/4H3R3方案用于初治涂阳肺结核无空洞病例是适宜的,初治涂阳肺结核空洞病例应首选2HRZE/4HR方案。
Objective To explore the short-term effects of short-course chemotherapy （drugs used daily or intermittently） on initial smear positive cavernous pulmonary tuberculosis. Methods 81 patients with initial smear positive cavernous pulmonary tuberculosis were randomly assigned to receive 2HRZE/4HR program （n = 40, group A） or 2H3R3Z3E/4H3R3 program （n = 41, group C）, another 82 patients with initial smear positive non-cavernous pulmonary tuberculosis were randomly assigned to receive 2HRZE/4HR program （n = 41, group B） or 2H3R3Z3E3/4H3R3 program （n = 41, group D）. The based line data, such as age and sex, were the same among the 4 groups. Results Sputum negative conversion rates at 2 and 3 months after treatment and recovery rate were 92.50%, 95.00%, and 92.50% in group A ; Those were 95.12%, 97.56%, and 97.56% in group B （group A vs group B, P = 0.65, 0.55, or 0.30）; Those were 82.93%, 87.80 %, and 75.61% in group C; and those were 95.12%, 95.12%, and 92.68% in group D （group C vs group D, P = 0.08, 0.075, or 0.03）. The recovery rate in group A was significantly higher than that in group C （P = 003）. Conclusion 2H3R3Z3E3/4H3R3 program is appropriate for initial smear positive non-cavernous pulmonary tuberculosis, and 2HRZE/4HR program can be the first choice for initial smear positive eavernous pulmonary tuberculosis.
出处
《实用医学杂志》
CAS
北大核心
2009年第9期1401-1403,共3页
The Journal of Practical Medicine
关键词
化疗
治疗
肺结核空洞病例
疗效
临床
Tuberculosis, pulmonary
Short-course chemotherapy program
Full range intermittent short-course chemotherapy program
Results
