摘要
目的研究抗结核固定剂量复合剂(FDC)的有效性和安全性,探索结核病有效安全的用药方案。方法随机抽取初治涂阳患者200例,分为观察组[2(费宁+E)/4(费安)]和对照组(2H3R3Z3E3/4H3R3)各100例。对两组患者的治疗效果、不良反应进行分析比较。结果 观察组和对照组用药2个月末痰菌阴转率分别为92.93%和91.84%,满疗程痰菌阴转率提高到98.99%和96.94%,两组2个月末和满疗程x线胸片吸收有效率分别为90.00%、93.88%和96.00%、100%,满疗程空洞闭合率为61.90%和65.79%,两组痰菌阴转率、x线胸片吸收率和空洞闭合率差异均无显著性意义(P>0.05);观察组和对照组临床不良反应率分别为20.20%和35.71%,差异有显著性意义(P<0.05),其中WBC或PLT异常率分别为20.20%和24.49%,ALT异常率分别为14.14%和12.24%。结论 固定剂量复合剂与国家标准治疗方案效果相当,用药剂量易于调整,不良反应较少,具有一定的推广应用前景。
Objective To analyze the effect and safety of the fixed-dose combination therapy in Wuhan. Methods Two hundred initial smear-positive pulmonary tuberculosis patients were randomly selected and allocated equally into two groups,treatment and control groups.The result and side effect were compared between the two groups. Results By the end of two months the sputum negative conversion rate were 92.93% and 91.84% respectively in two groups,and by the end of six months the sputum negative conversion rate were enhanced to 98.99 % and 96.94% respectively in two groups.The X ray effective-absorption rate were Hubei Provincial Center for Disease Control and Prevention,d 93.88% to 96.00% and 100% reapectively.The cavity closure rates in the two groups were 61.90% and 65.79% by the end of six months.There were no significant statistical difference between the two groups in the rate of sputum negative conversion,X ray absorption and cavity closure（P0.05）.The occurrence rate of adverse reaction in two groups were 20.20% and 35.71% with significant statistical difference（P0.05）,abnormality of WBC and ALT in the treatment group were 20.20% and 14.14%,while in the control group,24.49% and 12.24 %. Conclusion The effect of fixed-dose Combination therapy was as effective as the standard national anti-tuberculosis chemotherapy.However,the former was easier for adjusting the drug dose,the adverse effect was lesser,thus it may be popularized in practical treatment.
出处
《公共卫生与预防医学》
2011年第4期35-38,共4页
Journal of Public Health and Preventive Medicine
关键词
固定剂量复合剂
肺结核
初治涂阳
效果
Fixed-dose Combination therapy
Tuberculosis
Initial smear-positive patients
Effect
