摘要
硒是哺乳动物和人必需的微量元素。硒的生物学功能主要是以硒蛋白的形式表现的。到目前为止，已经克隆并测定ｃＤＮＡ顺序的哺乳动物硒蛋白有９种，它们是细胞内谷胱甘肽过氧化物酶、细胞外谷胱甘肽过氧化物酶、磷脂氢谷胱甘肽过氧化物酶、胃肠谷胱甘肽过氧化物酶、Ⅰ型碘化甲状腺原氨酸５′脱碘酶、Ⅱ型碘化甲状腺原氨酸５′脱碘酶、Ⅲ型碘化甲状腺原氨酸５′脱碘酶、硒蛋白Ｐ和硒蛋白Ｗ。这些硒蛋白中硒参入到蛋白分子是通过硒半胱氨酸ｔＲＮＡ识别ｍＲＮＡ中特异的ＵＧＡ密码子将硒半胱氨酸插入到硒蛋白中。
Selenium is an essential trace element for animals and humans. Selenium exerts its biological function largely through selenoproteins. Up to now nine selenoproteins'cDNAs have been cloned and sequenced, which are cellular glutathione peroxidase(cGPX), extracellular glutathine peroxidase(eGPX), phospholipid hydroperoxidase glutathione peroxidase(PHGPX), gastrointestinal glutathione peroxidase (GPXGI), type Ⅰ iodothyronine 5′deiodinase (IDⅠ),type 2 iodothyronine 5′deiodinase(IDⅡ), type Ⅲ iodothyronine 5deiodinase(IDⅢ), selenoprotein P (SeP) and selenoprotein W. In all these selenoproteins Se is incorporated into the protein molecule via the selenocysteinyltRNA which recognizes the specific UGA codons in mRNA to insert selenocysteine into the primary structure of selenoproteins.
出处
《生理科学进展》
CAS
CSCD
北大核心
1998年第1期27-34,共8页
Progress in Physiological Sciences
关键词
硒
硒蛋白
哺乳动物
Selenium
Selenoprotein
Biological function
Expression and regulation
