摘要
目的探讨3种肿瘤标志物联合应用在胆管癌诊断、疗效判断中的价值。方法利用酶联免疫吸附法(ELISA)检测35例胆管癌及50例胆道良性疾病患者的血清细胞间黏附分子-1(sICAM-1)水平,同时用电化学发光免疫法检测糖类抗原19-9(CA19-9)、癌胚抗原(CEA)的水平。结果血清CA19-9在胆管癌中敏感性为80.0%、特异性为86.0%,在3项指标中最高,CA19-9与sICAM-1联合应用敏感性提升到88.6%,特异性为80.0%。结论CA19-9与sICAM-1联合应用,检测胆管癌的敏感性和特异性均较好。
Objective To evaluate the diagnostic value of combined detection of serum levels of CEA, CA19 -9 and slCAM - 1 for cholangiocaroinoma. Methods The Serum levels of CEA and CA19 -9 in 35 patients with cholangiocarcinoma and 50 patients with benign biliary tract diseases were detected by electrochemical luminescence method, and their serum level of sICAM - 1 was measured with ELISA method. Resuits The sensitivity and specificity of CA19 -9 was highest among these 3 markers, and its sensitivity and specificity were 80% and 86% respectively. Its sensitivity and specificity could be raised to 88.6% and 80% respectively by combined detection of CA19 -9 with slCAM - 1. Condusion The combined detection of CA19 - 9 and slCAM - 1 can raise the sensitivity and specificity in diagnosis of cholangioeareinoma
出处
《临床和实验医学杂志》
2009年第5期7-8,共2页
Journal of Clinical and Experimental Medicine
