摘要
N-甲基-D-天冬氨酸（NMDA）受体在学习记忆产生中所起的作用一直是人们关注的焦点。研究表明，突触后膜NMDA受体通道开放、Ca2＋内流、第二信使的激活及其导致的下游蛋白磷酸化和表达增加是学习记忆产生的主要途径。多种因素引起的学习记忆功能行为的改变，均与NMDA受体的变化有关。本文总结了近年来海马NMDA受体与学习记忆产生关系的研究进展，以便进一步探讨海马NMDA受体参与学习记忆形成的神经机制。
Recent years, researchers have paid close attention to the role of N-methyl-D-aspartate recep- tor in study, some researches have proved that the activation of N-methyl-D-aspartate receptor play a mail role in the study, that the inflowing of Ca2 ＋ which mediated by the breaking of N-methyl-D-aspartate receptor in postsynaptic membrane, the activation of second messenger, phosphorylation and expression of downstream protein are major route in study. Various damages of study result from the change of N-methyl-D-aspartate re- ceptor. This paper is a review of N-methyl-D-aspartate receptor in study to find out the neuromechanism of study.
出处
《医学综述》
2009年第10期1452-1455,共4页
Medical Recapitulate
基金
广州市科技计划项目资助(2007J1-C0171)
