摘要
目的：介绍新一代Ｈ１受体拮抗剂西替利嗪。方法：通过复习近１０年的文献，对西替利嗪的药理、药效、药动和临床应用进行综述。结果：西替利嗪可选择性拮抗外周Ｈ１受体，有抗组胺、抗过敏等活性。结论：西替利嗪作用强而持久，且无中枢镇静作用，值得进一步研究和临床推广应用。
OBJECTIVE:To introduce cetirizine. METHODS:The pharmacology, pharmacodynamics, pharmacokinetics, and clinical uses of the drug in the last ten years were reviewed. RESULTS:Cetirizine could selectively react with peripheral H1receptors with antihistamine and antiallergic actions. CONCLUSION:Cetirizine is a lowsedative antihistamine with rapid onset of action and it is worthy to be used in clinical.
出处
《中国新药杂志》
CAS
CSCD
1998年第2期94-97,共4页
Chinese Journal of New Drugs
关键词
西替利嗪
H1受体拮抗剂
药理
药代动力学
Cetirizine
H1receptor antagonist
Pharmacodynamic properties
Pharmacokinetic properties
Adverse effects
