摘要
目的：建立大鼠外伤后癫痫模型并观察脑铁离子的代谢变化。方法：将铁离子注射到SD大鼠大脑感觉运动皮层,对照组给予相同操作但不注射铁离子。用火焰原子吸收光谱法测定脑组织中铁含量。结果：模型大鼠的脑铁含量在观察时间段呈逐渐降低的趋势。结论：铁可能是是外伤后癫痫形成机制的始动因素。
Objective：To get the rat model of posttraumatic epilepsy and observe the change of iron metabolism in the brain of the posttraumatic epilepsy（PTE） animal model.Methods：FeCl3 was injected over a period of 5 minute into the sensorimotor cortex by a microinjection syringe.The control group was treated by same operation,but no iron introduction.Detected the content of the iron in the brain tissue by Flame Atomic Absorption Spectrometry.Results： The content of the iron was decreased in the brain tissue of the posttraumatic epilepsy animal model,and had a tendency of decrease with the development of time.Conclusions： Iron may be an onset factor of the mechanism of PTE.
出处
《中国民康医学》
2009年第9期957-959,共3页
Medical Journal of Chinese People’s Health
关键词
外伤后癫痫
氯化铁
脑电图
Posttraumatic Epilepsy
Ferric Chloride
Electroencephalograms
