摘要
目的探讨口服葡萄糖耐量试验（OGTT）1h血糖（1hPG）升高与老年男性原发性高血压患者动脉硬化的相关性。方法将126例老年男性原发性高血压患者根据OGTT结果分为1hPG正常的正常糖耐量组、1hPG升高组、糖耐量异常组和糖尿病组，比较不同组间各代谢指标及颈动脉内中膜厚度（IMT）。结果1hPG升高组1hPG（12．0±1．1）mmol／L与糖尿量异常组（11．1±1．8）mmol／L相似，高于正常糖耐量组（9．1±1．4）mmol／L（P〈0．01），低于糖尿病组（P〈0．01）；IMT值在4组内递增（P〈0．05），1hPG升高组IMT值为（1．02±0．12）mm；1hPG为颈动脉IMT的独立相关因素（P〈0．01）。结论男性高血压人群1hPO升高较糖耐量异常更早出现，与动脉硬化相关。
Objective To observe the correlation between 1-hour postload plasma glucose and carotid intima-media thickness （IMT） in elderly male patients with hypertension. Methods One hundred and twenty six elderly male patients with hypertension were enrolled and divided into four groups： normal glucose tolerance with normal 1h plasma glucose （1hPG） group （low NGT, n=42）; normal glucose tolerance with high 1 h plasma glucose group （high-NGT, n= 23）; impaired glucose tolerance group （IGT, n=27） and diabetic group （n 34）. The differences of blood pressure, blood glucose, blood lipid and intimia-media thickness among groups were analyzed. Results OGTT 1 hPG in high NGT group was similar with IGT group[（12.0±1.1）mmol/L vs. （11.1±1.8）mmol/L, P〉0.05] ,but significantly higher than that in low NGT group [（12.0±1.1）mmol/L vs. （9.1±1.4） mmol/L, P〈0.01]. The value of IMT was gradually increased in four groups （P〈0.05） and it was （1.02±0. 12） mm in high NGT group. OGTT 1 hPG was the independent risk factor for IMT（P〈 0.01）. Conclusions OGTT 1h plasma glucose is associated with atherosclerosis in elderly male hypertensive people.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2009年第5期371-373,共3页
Chinese Journal of Geriatrics
关键词
血糖
颈动脉
血管内膜
动脉粥样硬化
高血压
Blood glucose
Carotid arteries
Tunica intima
Atherosclerosis
Hypertension
