摘要
目的:原发性高血压人群常伴发糖代谢紊乱,而高血压合并糖代谢异常后可加速心血管并发症的发生发展,致残率和致死率较高。观察安庆农村地区高血压人群血糖代谢异常情况,并探讨可能的影响因素。方法:①试验对象:试验从2005-06/2006-02安徽安庆农村地区开展高血压的临床流行病学研究中选择调查对象532人,均为男性,年龄50～75岁。纳入标准:患者的血压符合1999年世界卫生组织高血压诊断标准,排除继发性高血压,严重心血管疾病及肝肾功能不全,严重胃肠疾病,糖尿病,甲亢,肿瘤及其他疾患,所有调查对象均自愿参加,并签署了知情同意书。②试验方法:对所有受试者进行问卷调查并收集相关体检资料。③试验评估:运用单因素和多因素非条件Logistic回归探讨影响糖代谢的因素。结果:纳入调查对象532人,均进入结果分析。①该高血压人群中共有122人空腹血糖异常,总检出率为22.68%;除舒张压和总胆固醇外,血糖正常者与血糖异常者之间相比较,其他指标差异均有显著性(P<0.01,P<0.05)。②单因素非条件Logistic回归分析显示,吸烟、教育程度、吃肉习惯等是血糖代谢异常的危险因素。③多因素分析显示年龄、体质量指数、吸烟、高密度脂蛋白胆固醇、吃肉习惯、烹饪用油、腌制品摄入、甜食摄入与血糖代谢异常有关。结论:高血压人群血糖代谢异常检出率较高,提示在治疗血压的同时需要注意血糖的控制,提倡合理膳食,从而降低心血管事件的发生。
AIM: Abnormal glucose metabolism often occurs in essential hypertension population. This condition may accelerate the development of blood vessel complication and increase the fatality rate and physical disability rate. This study investigated the incidence of abnormal glucose metabolism in rural people with essential hypertension and explored the possible risk factors. METHODS: ①532 male essential hypertensive patients aged 50-75 years were selected from a hypertensive clinical epidemiology study in Anhui rural areas between June 2005 and February 2006. The blood pressure of patients met the diagnosis criteria of WHO in 1999 and patients with secondary hypertension, chronic cardiovascular disease, chronic liver, renal diseases, severe stomach intestine diseases, diabetes, hyperthyreosis, tumors and other diseases were excluded. The written informed consent was obtained from all participants. ②All subjects were surveyed using questionnaire, and the medical examination information were collected. ③Single and multiple non-conditional Logistic regression was used to analyze the risk factors for abnormal glucose metabolism. RESULTS: All 532 subjects were involved in the result analysis. ①There were 122 patients with abnormal fasting glucose and the total detection rate was 22.68%. Except total cholesterol and diastolic blood pressure, there were statistical differences in other indexes between people with normal and abnormal glucose metabolism (P < 0.01, P < 0.05). ②Single Logistic regression analysis showed that smoking, education, meat dinner, et al were the risk factors for abnormal glucose metabolism. ③Multiple factor Logistic regression analysis showed that age, body mass index, smoking, high density lipoprotein cholesterol, meat dinner habit, cooking oil, sweetmeat intake, salted food intake were associated with abnormal glucose metabolism. CONCLUSION: The detection rate of abnormal glucose metabolism is high in people with essential hypertension. This suggests that blood glucose should be paid more
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2007年第51期10312-10315,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
