摘要
目的:观察拉坦前列素治疗常规抗青光眼药不能控制眼压的闭角型青光眼的疗效。方法:用其它抗青光眼药眼压控制未达正常的闭角型青光眼患者23例36只眼,给予拉坦前列素单独用药或联合噻吗洛尔、毛果芸香碱,用药6个月,观察眼压、视力、视野及不良反应。结果:急性闭角型青光眼慢性期组治疗前平均眼压(27.13±5.21)mmHg,治疗6个月平均眼压(16.21±3.45)mmHg,治疗前、后差异有统计学意义(P<0.05);慢性闭角型青光眼组治疗前平均眼压(23.25±7.71)mmHg,治疗6个月平均眼压(17.19±3.64)mmHg,治疗前、后差异有统计学意义(P<0.05)。所有病例视力、视野无变化,不良反应轻微。结论:对于用其它抗青光眼药不能控制眼压的闭角型青光眼患者,拉坦前列素单独用药或联合用药效果良好。
OBJECTIVE： To evaluate the efficacy of latanoprost for patients with refractory angle-closure glaucoma in whom the intraocular tension failed to be kept under control by common anti - glaucoma drugs. METHODS： A total of 23 refractory glaucoma cases （36 eyes） whose intraocular pressure （IOP） failed to be kept under control by common anti- glaucoma drugs were assigned to receive latanoprost alone or latanoprost combined with timolol or pilocarpine for 6 months. The intraocular tension, visual acuity, visual field and side- effect were observed. RESULTS： In acute primary angle- closure glaucoma group, the mean IOP was（27.13 ± 5.21） mmHg before treatment vs. （16.21 ± 3.45） mmHg at six months（P 〈 0.05）;in chronic primary angle - closure glaucoma group, the mean IOP was（23.25 ± 7.71） mmHg before vs. （ 17.19 ± 3.64） mmHg at six months（P 〈 0.05）. There were significant difference before and after treatment in two groups（P 〈 0.05）. For all cases, no change was noted in either visual acuity or visual fields and in whom the side - effects were mild. CONCLUSION ： Latanoprost alone or in combination with timolol or pilocarpine has remarkable efficacy for refractory primary angle - closure glaucoma in patients whose intra-ocular tension failed to be brought back to normal using common anti- glaucoma drugs.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第14期1090-1091,共2页
China Pharmacy
关键词
拉坦前列素
眼内压
闭角型青光眼
Latanoprost
Intraocular pressure
Angle - closure glaucoma
