摘要
目的:比较国产与进口紫杉醇对荷瘤小鼠的抗肿瘤疗效及毒副反应。方法:小鼠接种S180后随机分为4组,即模型对照组(生理盐水)、进口紫杉醇组、国产紫杉醇A组、国产紫杉醇B组,各组于接种后1、3、5d尾静脉注射给予相应药物(紫杉醇组剂量均为10mg.kg-1)。随后观察各组的抑瘤作用,检查小鼠肝功能及血液系统指标变化,观察生存时间。结果:上述检测指标国产与进口紫杉醇制剂比较均未见显著性差异(P>0.05)。结论:相同给药剂量(10mg.kg-1)下,小鼠体内抗肿瘤疗效及毒副反应国产与进口紫杉醇制剂相似。
OBJECTIVE： To evaluate the antitumor efficacy and safety of domestic vs. imported paclitaxel in intumorbearing mice. METHODS： The mice were inoculated with S180 and randomly assigned to one of the following 4 groups： model group （normal saline）, imported paclitaxel group, domestic paclitaxel group A and B. At 1, 3, and 5 days after intravenous administration of corresponding drugs （the dosage of paclitaxel was 10mg·kg^-1 in all groups）. The antitumor activity and the survival time of the mice were observed, and the hepatic function and the hematological indexes of each group were detected. RESULTS： There were no significant differences between the domestic and the imported paclitaxel - treated mice in the above-mentioned indexes （P 〉0.05）. CONCLUSION： At the same dosage （10mg·kg^-1）, the domestic paclitaxel is similar to the imported paclitaxel in antitumor effect and toxic side effects.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第13期986-988,共3页
China Pharmacy
关键词
紫杉醇
抗肿瘤作用
小鼠
肝功能
Paclitaxel
Antitumor effect
Mice
Hepatic functions
