摘要
糖尿病视网膜病是糖尿病最常见和严重的微血管并发症之一。近年来大量研究表明,氧化应激和糖尿病视网膜病变的发生发展有一定的相关性。高血糖引起体内氧化应激反应,氧化应激又通过损害内皮细胞、线粒体,生成异常代谢通路,促进炎性反应等加重对视网膜组织的损害,造成视网膜缺血、甚至脱离等严重后果;而抗氧化治疗在临床上也取得了一定的成效。本文主要围绕氧化应激和糖尿病视网膜病的发病关系展开综述。
Diabetic retinopathy is one of the most common and serious chronic complications. Recently, great quantities of researches show that there are correlations between the oxidative stress and the diabetic retinopathy. Hyperglycemia causes the oxidative stress, and it damages the retina through injuring the endothe- lial cells and mitochondria, generating abnormal me- tabolism pathway and promoting the inflammatory re- sponse, then the serious consequences have been caused such as retinal ischemia or even detachment. In clinic the antioxidant treatment has achieved some resuits. So this paper focuses on the relationship of the oxidative stress and the incidence of the diabetic retinopathy.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第3期356-360,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
氧化应激
糖尿病视网膜病
活性氧簇
oxidative stress
diabetic retinopathy
reactive oxygen species
