期刊文献+

Secretagogin在45例胃癌及其周围组织中的表达

Secretagogin Expression in Gastric Cancer Tissue and Cancer Surrounding Tissue
原文传递
导出
摘要 [目的]探讨Secretagogin(SCGN)在胃癌及其癌旁正常组织中的表达。[方法]采用免疫组化方法测定45例胃癌及其癌旁正常组织中SCGN的表达,并与传统神经内分泌标志物进行比较。[结果]SCGN在胃癌组织中阳性表达率为13.3%(6/45),周围正常黏膜中阳性表达率为86.6%(P<0.05),低分化及印戒细胞胃癌组织中SCGN表达高于高、中分化胃癌,T3~4期SCGN表达高于T1~2期(P<0.05)。[结论]SCGN与胃癌的发生发展及预后有关,有可能成为胃癌重要的生物学标志物。
出处 《肿瘤学杂志》 CAS 2009年第4期330-332,共3页 Journal of Chinese Oncology
  • 相关文献

参考文献8

  • 1Alazard R, Blaud M, Elbaz S, et al. Identification of the 'NORE' (N-Oct-3 responsive element), a novel structural motif and composite element[J]. Nucleic Acids Res, 2005, 33(5): 1513-1523. 被引量:1
  • 2Wagner L, Oliyarnyk O, Gartner W, et al.Cloning and expression of secretagogin, a novel neuroendocrine and pancreatic islet of Langerhans-specific Ca^2+-binding protein [J]. J Biol Chem, 2000, 275(32): 24740-24751. 被引量:1
  • 3Gartner W, Lang W, Leutmetzer F, et al. Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein[J]. Cereb Cortex, 2001, 11(12): 1161-1169. 被引量:1
  • 4Zierhut B, Daneva T, Gartner W, et al. Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene[J].Biochem Biophys Res Commun, 2005, 329(4): 1193-1199. 被引量:1
  • 5Xing X, Lai M, Gartner W, et al. Identification of differentially expressed proteins in eoloreetal cancer by proteomics: down-regulation of seeretagogin[J]. Proteomics, 2006, 6(9): 2916-2923. 被引量:1
  • 6邢晓明,王英红,黄琼,吕炳建,来茂德.应用蛋白质组学分析结直肠癌促泌素和糖调节蛋白78蛋白变化及其意义[J].中华病理学杂志,2007,36(2):107-112. 被引量:9
  • 7Kasprzak A, Zabel M, Biczysko W. Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocline pulmonary turnouts[J]. Pol J Pathol, 2007, 58(1): 23-33. 被引量:1
  • 8Lai M, Lti B, Xing X, et al. Secretagogin, a novel neuroendoerine marker, has a distinct expression pattern from chromogranin A[J]. Virchows Arch, 2006, 449(4):402-409. 被引量:1

二级参考文献18

  • 1邢晓明,来茂德.蛋白质组学在消化系统肿瘤中的应用[J].中华病理学杂志,2003,32(5):459-462. 被引量:4
  • 2白雪,李世拥,安萍,于波,蔡慧云.结直肠癌原发灶和肝转移灶组织中蛋白质组差异表达及临床意义[J].中华医学杂志,2005,85(30):2128-2131. 被引量:8
  • 3Ding SJ,Li Y,Shao XX,et al.Proteome analysis of hepatocellular carcinoma cell strains,MHCC97-H and MHCC97-L,with different metastasis potentials.Proteomics,2004,4 (4):982 -994. 被引量:1
  • 4Witzmann FA,Bai F,Hong SM,et al.Gels and more gels:probing toxicity.Curr Opin Mol Ther,2004,6(6):608-615. 被引量:1
  • 5Rocken C,Ebert MP,Roessner A.Proteomics in pathology,research and practice.Pathol Res Pract,2004,200(2):69-82. 被引量:1
  • 6Wagner L,Oliyarnyk O,Gartner W,et al.Cloning and expression of secretagogin,a novel neuroendocrine-and pancreatic islet of Langerhans-specific Ca^2 + -binding protein.J Biol Chem,2000,275(32):24740-24751. 被引量:1
  • 7Gartner W,Lang W,Leutmetzer F,et al.Cerebral expression and serum detectability of secretagogin,a recently cloned EF-hand Ca (2 +)-binding protein.Cereb Cortex,2001,11 (12):1161-1169. 被引量:1
  • 8Desiderio DM,Zhan X.The human pituitary proteome:the characterization of differentially expressed proteins in an adenoma compared to a control.Cell Mol Biol (Noisy-le-grand),2003,49(5):689-712. 被引量:1
  • 9Haas IG.BiP (GRP78),an essential hsp70 resident protein in the endoplasmic reticulum.Experientia,1994,50(11-12):1012-1020. 被引量:1
  • 10Lee AS.The glucose-regulated proteins:stress induction and clinical applications.Trends Biochem Sci,2001,26 (8):504-510. 被引量:1

共引文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部