摘要
目的建立HPLC法测定氨甲环酸片溶出度的检测方法。方法采用十八烷基硅烷键合硅胶柱（C18柱，Diamonsil，4．6mm×250mm，5μm）；流动相：0．23％十二烷基硫酸钠溶液（用磷酸调节pH至2．5）-甲醇（60：40）；检测波长：220nm；流速：1．0mL·min^-1；进样量：100扯L；柱温：30℃。结果氨甲环酸在29．76～357．12μg·mL^-1具有良好的线性关系（r=0．9999）；平均回收率为99．61％，RSD为0．45％（n=9）。结论本法简便、快速、准确、专属性好，为中国药典2010年版氨甲环酸片溶出度的修订提供了依据。
Objective To establish an HPLC methed for the dissolution of tranexamic acid tablets. Methods C18 （Diamonsil, 4. 6 mm×250 mm, 5μm） was used with 0. 23% of sodium laurilsulfate-methanol （60 ： 40） as the mobile phase. The detection wavelength was 220 nm. The flow rate was 1.0 mL ·min 1. The temperature was 30 ℃. Resuits The linear range of atorvastatin was 29.76 ～ 357.12 μg· mL 1 （r= 0. 999 9） . The average recover was 99. 61%, with RSD of 0.45% （n=9） . Conclusion The method is simple, rapid and accurate. It provides reference for China Pharmacopoeia （2010） to set a standard for the dissolution of tranexamic acid tablets.
出处
《中南药学》
CAS
2009年第4期280-282,共3页
Central South Pharmacy
