摘要
目的:将体外循环体腔热灌注顺铂(DDP)应用于恶性间皮瘤、消化道肿瘤和肺癌所致恶性浆膜腔积液的控制,观察其对恶性积液的治疗效果。方法:选择经病理组织学或细胞学确诊或影像学结合肿瘤标志血清学检查临床诊断的恶性间皮瘤、肝癌、胃癌、胰腺癌、大肠癌和肺癌,同时伴发恶性浆膜腔积液的患者54例,治疗前后客观测量积液量。用TRL型体外循环灌注热化疗治疗系统将DDP应用于浆膜腔恶性积液的控制,治疗间隔48h,每周期3次,3周为1个周期,治疗1个周期后评价积液控制效果,6周后确认疗效,10周后随访,再次评价疗效。结果:5例恶性间皮瘤1个周期后CR3例,PR2例,NE0例;2例PR患者进行第2个周期治疗后转为CR,6周后确认疗效均为CR;10周后随访有2例复发,积液再次出现。41例消化道肿瘤伴发的恶性胸腔积液和腹水,1个周期后CR25例,PR10例,NE6例,临床有效率为85%;10周后随访确认疗效,41例患者有20例仍为CR,PR10例,NE11例,临床获益率为73%。8例肺癌并发的恶性胸腔积液,1个周期后CR5例,PR2例,NE1例;10周后随访结果为CR4例,PR2例,NE2例,临床有效率为75%。结论:体外循环胸腹腔热灌注DDP区域性热化疗可用于治疗恶性间皮瘤、消化道肿瘤和肺癌伴发的恶性浆膜腔积液,积液控制效果显著。
OBJECTIVE： To investigate the clinical effect of coelore hyperthermia perfusion extracorporeal circulatory system in combination with cisplatin in the treatment of malignant effusions caused by malignant mesothelioma, alimentary tract carcinoma and lung cane er. METHODS： The patients with malignant mesothelioma, lung cancer and alimentary tract carcinoma （including liver cancer, gastric cane er, pancreatic cancer, and colon cancer）, diagnosed by pathological evidences or image and serum tumor markers, following malignant effusions, were treated by coelom hyperthermia perfusion extracorporeal circulatory system in combination with cisplatin. The treatment was performed 1 circulation per 48 h, and 1 cycle included 3 circulations, 21 d. The volume of effusions was examined at the begining and 1 cycle later. After 6 weeks, the efficacy was evaluated again, and being followed up for 10 weeks. RESULTS： 1）There were 3 cases of complete response （CR）, 2 cases of partial response （PR）, and 0 cases no effect （NE） in 5 cases of malignant mesothelioma after 1 cycle; and the 2 cases of PR became CR after 2 cycles. Six weeks later, the effect on all patients was CR. Following up for 10 weeks, the effusions had a relapse in 2 cases. 2）There were 25 cases of CR, 10 cases of PR, and 6 cases NE in 41 cases of alimentary tract carcinoma accompanied by malignant effusions after 1 cycle, the clinical profit rate was 85%.Following up for 10 weeks, there were 20 cases of CR, 10 cases of PR, and 11 cases of NE, and the clinical profit rate was 73%. 3）There were 5 cases of CR, 2 cases of PR, and 1 cases NE in 8 cases of lung cancer accompanied by malignant effusions after 1 cycle. Following up/or 10 weeks, there were 4 cases of CR, 2 cases of PR, and 2 cases of NE, and the clinical profit rate was 750/00. CONCLUSION： Coelom hyperthermia perfusion extracorporeal circulatory system in combination with cisplatin can treat malignant effusions caused by malignant mesothelioma, alimentary tract cancer （liver can
出处
《中华肿瘤防治杂志》
CAS
2009年第5期381-383,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
肿瘤/治疗
体外循环
灌注
局部
neoplasms/therapy
extracorporeal circulation
perfusion, regional
