摘要
目的:通过动物实验,探讨骨诱导活性材料(osteoinduction active material,OAM)对种植体周围骨缺损的修复能力,为临床应用提供实验依据。方法:Beagle犬4只,拔除双侧下颌第一、二前磨牙,将每只犬的两侧实验牙位随机分为实验侧和对照侧。拔牙后3个月植入种植体,建立种植体周围骨缺损模型。实验组种植体周围骨缺损区植入OAM,对照组植入磷酸三钙。于植入后第8、16周分别处死2只动物,进行组织学、扫描电镜观察,测量骨密度,能谱分析种植体—新骨界面Ca2+含量,采用SPSS13.0软件包对数据进行t检验。结果:8周时,实验组新骨与种植体形成区段性骨结合,对照组种植体边缘为纤维性界面。实验组与对照组骨密度差异无统计学意义(P>0.05),实验组种植体—新骨界面Ca2+含量(22.16±3.33)显著高于对照组(3.13±2.44)(P<0.05)。16周时,实验组新生骨与种植体形成骨整合,对照组为纤维性结合。实验组骨密度显著高于对照组(P<0.05),实验组种植体—新骨界面Ca2+含量(42.23±6.20)显著高于对照组(10.40±3.12)(P<0.05)。结论:OAM能促进种植体周围骨缺损修复,并促进种植体—骨界面形成较完善的骨整合。
PURPOSE： To explore the potential of using osteoinduction active material （OAM）for reconstruction of bone defects of peri-implant by animal experiment, and provide experimental evidence for clinical application. METHODS： Four Beagle dogs underwent extraction of the mandibular first and second premolar to create edentulous regions. 2 groups were divided randomly. Three months later, titanium implants were inserted and peri-implant bone defect models were established. The bone defects were repaired with OAM in the experimental group and repaired with tricalcium phosphate （TCP）in the control group. Two animals each were sacrificed at the end of 8 weeks and 16 weeks respectively. The specimens were evaluated with histological examination, scanning electric microscope, bone density examination, and energy disperse analysis of Ca^2＋. The data was analyzed with SPSS13.0 software package for Student＇s t test. RESULTS： At 8-week,some parts of implants in the experimental group were directly contacted with new bone. There were fibers between the bone and implant in the control group. There was no significant difference between the experimental group and the control group in bone density （P〉0.05）. The percentage of Ca^2＋ of the experimental group （22.16±3.33） was significantly greater than that of the control group （3.13±2.44） （P〈0.05）. At 16-week, there was good osseointegration between the bone and implant in the experimental group but no new bone formation in the control group. The bone density of the experimental group was significantly greater than that of the control group （P〈0.05）. The percentage of Ca2~ of the experimental group （42.23 ±6.20） was significantly greater than that of the control group （10.40±3.12） （P〈0.05）. CONCLUSION： The results suggest that OAM can effectively accelerate the reconstruction of peri-implant bone defects and improve the osseointegration in the interface between the implant and bone. Supported by Science and Technology Re
出处
《上海口腔医学》
CAS
CSCD
2009年第2期189-193,共5页
Shanghai Journal of Stomatology
基金
沈阳市科学技术计划项目(1081269-9-00)~~
关键词
种植牙
骨缺损
骨整合
骨诱导活性材料
Dental implant
Bone defect
Osseointegration
Osteoinduction active material
