期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

转化生长因子β1在肝纤维化发病中的作用 被引量：6

下载PDF
导出
摘要 转化生长因子(TGF)β1在肝纤维化的启动、进展中发挥了关键作用,近年对其参与肝纤维化发生的机制有了新的认识,如TGF-β1与非肝星状细胞来源的肌成纤维细胞(MFB)的联系、与上皮-间质转化(EMT)过程的联系以及TGF-β1基因多态性与肝纤维化的可能联系等。
作者 过建春 陈群伟 包剑锋 石伟珍 施军平 荀运浩
机构地区 浙江中医药大学附属杭州第六医院中西医结合病区
出处 《国际消化病杂志》 CAS 2009年第2期86-88,共3页 International Journal of Digestive Diseases
基金 浙江省自然基金资助项目(Y205410) 浙江省教育厅高校科研计划项目(20050860)
关键词 转化生长因子Β1 肝纤维化 基因多态性
分类号 R575.2 [医药卫生—消化系统] R135.2 [医药卫生—内科学]
  • 相关文献

参考文献20

  • 1ten Dijke P, Hill CS. New insights into TGF-β-Smad signalling. Trend Biochem Sci, 2004, 29: 265-273. 被引量：1
  • 2Liu C, Gaca MD, Swenson ES, et al. Smads 2 and 3 are differentially activated by transforming growth faetor-β(TGF-β) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Srnads in activated cells is TGF-β-independent. J Biol Chem, 2003, 278:11721 11728. 被引量：1
  • 3Uemura M, Swenson ES, Gaca MD, et al. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and smooth muscle aetin organization. Mol Biol Cell, 2005, 16: 4214-4224. 被引量：1
  • 4Dooley S, Hamzavi J, Breitkopf K, et al. Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats. Gastroenterology, 2003, 125: 178-191. 被引量：1
  • 5Kaimori A, Potter J, Kaimori J, et al. Transforming growth factor-β1 induces an epithelial-to-mesenehymal transition state in mouse hepatocytes in vitro. J Biol Chem, 2007, 282: 22089- 22101. 被引量：1
  • 6Robertson H, Kirby JA, Yip WW, et al. Biliary epithelial-mesenchymal transition in posttransplantation recurrence of primary biliary cirrhosis. Hepatology, 2007, 45:977-981. 被引量：1
  • 7Rygiel KA, Robertson H, Marshall HL, et al. Epithelial-mes enchymal transition contributes to portal tract fibrogenesis dur ing human chronic liver disease. Lab Invest, 2008, 88 112-123. 被引量：1
  • 8Zeisberg M, Hanai J, Sugimoto H, et al. BMP-7 counteracts TGF-β 1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med, 2003, 9: 964-968. 被引量：1
  • 9Wang S, Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor β in mesangial cells. J Biol Chem, 2004, 279: 23200-23206. 被引量：1
  • 10Zeisberg M. Bone morphogenic protein-7 and the kidney: current concepts and open questions. Nephrol Dial Transplant, 2006, 21: 568-573. 被引量：1

二级参考文献27

  • 1杨再兴,王皓,万谟彬,王晓今,徐玲玲,赵文静,高春芳.TGF-β1基因多态性对乙肝肝纤维化的影响[J].第二军医大学学报,2004,25(12):1288-1291. 被引量：7
  • 2[1]Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor beta in human disease[J]. N Engl J Med, 2000,342(18): 1350-1358. 被引量：1
  • 3[2]Bachem MG,Meyer D,Melchior R,et al. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived rom myofibroblast like cells. A potential mechanism of selfperpetuation in liver fibrogenesis[J]. J Clin Invest, 1992, 89(1):19-27. 被引量：1
  • 4[3]Gewaltig J,Mangasser-Stephan K,Gartung C,et al. Association of polymorphisms of the transforming growth factor-β1gene with the rate of progression of HCV-induced liver fibrosis [J]. Clin Chim Acta,2002,316(1-2) :83-94. 被引量：1
  • 5[4]Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitits C. The French METAVIR Cooperative Study Group[J]. Hepatology, 1994,20(1):15-20. 被引量：1
  • 6[5]Bedossa P,Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The French METAVIR Cooperative Study Group[J]. Hepatology,1996,24(2) :289-293. 被引量：1
  • 7[6]Bataller R, North, KE, Brenner DA. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal[J].Hepatology, 2003,37 (3): 493-503. 被引量：1
  • 8[7]Dunning AM, Ellis PD, McBride S, et al. A transforming growth factor beta 1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer[J]. Cancer Res, 2003,63 (10): 2610-2615. 被引量：1
  • 9[8]Holla LI,Fassmann A,Benes P,et al. 5 polymorphisms in the transforming growth factor-beta 1 gene (TGF-β1)in adult periodontitis[J]. J Clin P eriodontol , 2002 ,2 9 ( 4 ) :336-341. 被引量：1
  • 10[9]Tag CG, Mengsteab S, Hellerbrand C, et al. Analysis of the transforming growth factor-β1 (TGF-β1) codon 25 gene polymorphism by LightCycler-analysis in patients with hepatitis C infection[J]. Cytokine,2003,24(5): 173-181. 被引量：1

共引文献29

同被引文献75

引证文献6

二级引证文献33

国际消化病杂志
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部