摘要
以单甲氧基聚乙二醇(MPEG)、辛酸亚锡及L-丙交酯为原料,合成聚(乙二醇-L-乳酸)二嵌段共聚物(PELA),制备了PELA与α-环糊精的包结物.通过红外光谱分析、差示扫描量热分析、X射线衍射分析和核磁共振氢谱等方法对产物的结构和性能进行了表征.结果表明:PELA分子链被包结在α-CD分子形成的管道中,α-环糊精分子管道并排紧密排列,形成六方晶系的晶体;在包结物中PELA链活动被限制,无结晶和熔融现象;包结物中的α-环糊精与聚乙二醇嵌段重复单元的物质的量之比为1∶4.7.以上结果说明PELA与α-环糊精能够形成包结物.
Poly [ ethylene glycol-b- （L-lactide） ] （PELA） was synthesized, with monomethoxypolyethylene glycol （MPEG）, stannous octoate and L-lactide as the materials. The product then reacted with α-cyclodextrin to form an inclusion complex. Moreover, the structure and properties of the complex were characterized by infrared spectrosco- py （IR）, differential scanning calorimetry （DSC）, X-ray diffractometry （XRD） and 1H nuclear magnetic resonance （1H NMR） spectroscopy. It is shown that PELA polymer chains are included inside the molecular tube formed by multiple α-cyclodextrin molecules aligning into close-packed hexagonal crystalline structures, that there is no crystallization and melting behaviors in the complex because the chain motion of PELA is confined by α-cyclo- dextrin molecules, and that the molar ratio of ot-cyclodextrin to the repeating unit of polyethylene glycol block in the inclusion complex is 1 ： 4. 7. In conclusion, PELA is capable of forming inclusion complex with α-cyclodextrin.
出处
《华南理工大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2009年第3期14-18,共5页
Journal of South China University of Technology(Natural Science Edition)
基金
高等学校博士学科点专项科研基金资助项目(20050561020)
