摘要
目的:系统性评价乳铁蛋白联合标准疗法对Hpylori根除率的影响,及根除过程中的不良反应发生率.方法:从常用电子数据库检索标准三联或四联疗法联合与未联合乳铁蛋白根除Hpylori的随机临床试验,荟萃分析各项研究的根除率和不良反应发生率的合并OR值;进行亚组分析和敏感性分析;以漏斗图检测发表偏倚.结果:共9项随机临床试验(1343例)符合纳入标准.标准疗法联合与未联合乳铁蛋白按意向治疗(ITT)分析的Hpylori的根除率分别为86.57%(95%CI:83.99%-89.15%)和74.44%(95%CI:71.14%-77.74%),合并OR值为2.26(95%CI:1.70-3.00);总不良反应发生率分别为9.05%(95%CI:6.83%-11.27%)和16.28%(95%CI:13.43%-19.13%),合并OR值0.15(95%CI:0.04–0.54).结论:联合乳铁蛋白可有效提高标准疗法的Hpylori根除率,降低根除过程中的不良反应发生率.
AIM： To systematically evaluate whether adding lactoferrin to H pylori eradication regimens could improve eradication rates and reduce side effects during anti-H pylori treatment. METHODS： Eligible articles were identified by searching electronic databases. We included all randomized trials comparing lactoferrin supple- mentation to placebo or no treatment during an- ti-H pylori regimens. Statistical analysis was per- formed with Review Manager 5.0.10. Subanalysis/Sensitivity analysis was also performed. RESULTS： We identified 9 randomized trials （n=1343）. Pooled H pylori eradication rates for patients with and without lactoferrin were 86.57% （95% CI： 83.99%-89.15%） and 74.44% （95% CI： 71.14%-77.74%） by intention-to-treat analysis, respectively, and the odds ratio （OR） was 2.26 （95% CI： 1.70-3.00）; the occurrence of total side effects, especially nausea, for groups with or without lactoferrin were 9.05% （95% CI： 6.83%-11.27%） and 16.28% （95% CI： 13.43%-19.13%）, respectively; the summary OR was 0.15 （95% CI： 0.04-0.54）. CONCLUSION： Our review suggests that sup-plementation with lactoferrin could be effective in increasing eradication rates of anti-H pylori therapy, and could be considered helpful for patients with eradication failure.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第9期918-926,共9页
World Chinese Journal of Digestology
