摘要
目的探讨高原和平原原发性肾病综合征(nephrotic syndrome,NS)患者凝血功能指标的差异,为高原NS患者的诊治提供参考依据。方法以健康体检者为正常对照组(n=30),同期检测西藏军区总医院(高原组,n=30)和第三军医大学新桥医院肾内科(平原组,n=30)NS患者凝血酶原(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fib)、D-二聚体(D-Dimer)和血浆抗凝血酶Ⅲ(AT-Ⅲ)活性等指标,并对各组凝血抗凝指标的检验结果进行对比分析。结果与对照组相比,两组NS患者的PT、APTT均无显著差异(P>0.05),但Fib和D-D显著增高(P<0.01),AT-Ⅲ活性显著降低(P<0.01)。两组NS患者间相比,高原NS患者的Fib和D-D均显著高于平原NS组(P<0.01),而AT-Ⅲ活性明显低于平原NS组(P<0.01)。结论高原NS患者凝血活性较平原NS患者强,提示高原NS患者更需抗凝治疗。
Objective To investigate the difference of hypercoagulable state of the nephrotic syndrome patients who living at high altitude or in plain area in order to investigate the features of diagnosis and treatment for this disease at high altitude. Methods Nephrotic syndrome patients from the General Hospital of Tibetan Military Command （ above sea level 3 680 m, high altitude group, n = 30） and Xinqiao Hospital （ above sea level 300 m, plain group, n = 30） were enrolled in this study. Another 30 health individuals served as normal control. Prothrombin time （ PT）, activated partial thromboplastin time （ APTT）, and the levels of fibrinogen （Fib） and D-dimer, and content of antithrombin- Ⅲ （AT-Ⅲ ） were detected simultaneously. The detected results from 3 groups were compared. Results There was no significantly differences in PT and APTT among the 3 groups （ P 〉 0. 05 ） , and the levels of Fib and D-dimer were obviously higher but AT-Ⅲ was obviously lower in 2 NS groups than those in normal control group （P 〈 0.01 ）. Compared with 2 groups of nephrotic syndrome, the level of Fib and D-dimer was higher, but AT-Ⅲ was lower significantly in high altitude group than those of the plain group （P 〈0. 01 ）. Conclusion The activity of coagulation in nephrotic syndrome patients at high altitude is higher than those of nephrotic syndrome patients at the plain area.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2009年第8期751-753,共3页
Journal of Third Military Medical University
关键词
高原
肾病综合征
凝血功能
high altitude
nephrotic syndrome
indexes of coagulation
