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抗HIV药物血浆浓度的监测 被引量：2

Advancement on monitoring antive troviral drug concentration in plasma
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摘要 高效抗逆转录病毒疗法（highly active antiretroviral therapy，HAART）被认为是现今治疗HIV／AIDS最行之有效的办法，从根本上改变了人类HIV感染的临床进程。在多药联合应用过程中，个体间药代动力学差异等诸多因素影响药物在体内的作用发挥。为了提高药物的治疗效果，使得药物在有效浓度水平发挥效能，保证疗效的前提下毒副作用最低，临床开展药物浓度监测，帮助个体化剂量，优化治疗。 Highly active antiretroviral therapy （HARRT） is considered the best effective way of HIV/AIDS current treatments, and it has fundamentally changed the process of human HIV infection. Individual differences between the pharmacokinetics of drugs and many other factors play a role in the body in the course muhi-drug combination. In order to improve treatment outcomes, to reduce toxicity, to increase efficacy, TDM help to adjust the individual dose.
作者 李太生
机构地区 中国医学科学院北京协和医院感染科艾滋病诊疗中心
出处 《中华检验医学杂志》 CAS CSCD 北大核心 2009年第4期369-371,共3页 Chinese Journal of Laboratory Medicine
关键词 抗逆转录病毒治疗 高效 抗HIV药 血药浓度 Antiretroviral therapy, highly active Anti-HIV agents Plasma concentration
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献28

  • 1Morse GD, Catanzaro LM, Acosta EP. Clinical pharmacodynamics of HIV-1 protease inhibitors: use of inhibitory quotients to optimise pharmacotherapy. Lancet Infect Dis,2006,6:215-225. 被引量：1
  • 2徐叔云.治疗药物浓度监测.临床药理学.2版,北京:人民卫生出版社,2000. 被引量：1
  • 3Clark AJ. The reaction between acetyl choline and muscle cells. J Physiol, 1926,61:530-546. 被引量：1
  • 4Khoo SH, Lloyd J, Dalton M, et al. Pharmacologic optimization of protease inhibitors and nonnucleoside reverse transcriptase inhibitors(popin)-a randomized controlled trial of therapeutic drug monitoring and adherence support. J Acquir Immune Defie Syndr,2006,41:461-467. 被引量：1
  • 5Loregian A, Pagni S, Ballarin E, et al. Simple determination of the HIV protease inhibitor atazanavir human plasma by high-performance liquid chromatography with UV detection. J Pharm Biomed Anal,2006,42:500-505. 被引量：1
  • 6Streit F, Shipkova M, Armstrong VW, et al. Validation of a rapid and sensitive liquid chromatograp hy2tandem mass spectrometry method for free and total mycophenolic acid. Clin Chem ,2004,50 : 152-159. 被引量：1
  • 7Dickinson L, Robinson L, Tjia J, et al. Simultaneous determination of HIV protease inhibitors amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir in human plasma by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2005,829:82-90. 被引量：1
  • 8D'Avolio A, Sciandra M, de Requena DG, et al . An Improved HPLC Fluorimetric Method for the Determination of Enfuvirtide Plasma Levels in HIV-infected Patients. Ther Drug Monit ,2006,28 : 110-115. 被引量：1
  • 9Burger D, van der Heiden I, la Porte C, et al. Inter'patient variability in the pharmaeokinetics of the HIV non-nucleoside reverse transeriptase inhibitor efavirenz:the effect of gender, race, and CYP2B6 polymorphism. Br J Clin Pharmacol,2006,61:148-154. 被引量：1
  • 10Fletcher CV, Kawle SP, Kakuda TN, et al. Zidovudine triphosphate and lamivudine triphophate concentration-response relationship in HIV- infected persons. AIDS,2000,14:2137-2144. 被引量：1

二级参考文献19

  • 1朱余兵,邹健军,肖大伟,钱薇.国产齐多夫定片的血药浓度测定及相对生物利用度研究[J].中国药理学通报,2005,21(11):1404-1405. 被引量：2
  • 2CAHOURS X, THU TT, MESPLET N, et al. Analysis of intracellular didanosine triphosphate at sub-ppb level using LC-MS/MS [ J]. J Pharm Biomed Anal, 2001,26(5-6) :819-827. 被引量：1
  • 3REZK NL, TIDWELL RR, KASHUBA AD, et al. Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection [J]. J Chromatogr B, 2003, 791 (1-2): 137-147. 被引量：1
  • 4AYMARD G, LEGRAND M, TRICHEREAU N, et al. Determination of twelve antiretroviral agents in human plasma sample using reversed-phase high-performance liquid chromatography [ J]. J Chromatogr B, 2000, 744(1):227-240. 被引量：1
  • 5HUANG Y, ZURLINDEN E, LIN E, et al. Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid and tonsil tissue [J]. J Chromatogr B, 2004, 799(1) :51-61. 被引量：1
  • 6Drew RH, Weller S, Gallis HA, et al. Bioequivalence assessment of zidovudine (Retrovir) syrup, solution, and capsule formulation in patients infected with human immunodeficiency virus [ J ] . Antimicrob Agents Chemother, 1989 ;33:1801 - 1803. 被引量：1
  • 7Schrive I,Plasse JC. Quantification of zidovudine and one of its metabolites in plasma and urine by solid - phase extraction and high - performance liquid chromatography[J]. J Chromatogr B, 1994; 657:233-237. 被引量：1
  • 8Yuen GJ, Lou Y, Thompson NF, et al. Abacavir/lamivudine/zidovudine as combined formulation tablet: bioequivalence compared with each component administered concurrently and the effect of food on absorption[ J]. J Clin Pharmacol, 2001 ;41:277 -288. 被引量：1
  • 9Nebinger P, Koel M. Determination of serum zidovudine by ultrafiltration and high - performance liquid chromatography [ J ]. J Pharm Biomed Analysis, 1994 ;12:141 - 143. 被引量：1
  • 10Moore KHP, Raasch RH, Brouwer KLR, et al. Pharmacokinetics and bioavailability of ziodvudine and its glucuronidated metabolite in patients with hunan immunodeficiency virus infection and hepatic disease [ J ]. Antimicrob Agents Chemother, 1995 ;39:2732 - 2737. 被引量：1

共引文献7

同被引文献39

  • 1康来仪.从第16届世界艾滋病大会中获得的启示[J].微生物与感染,2007,2(1):44-50. 被引量：1
  • 2康来仪,潘孝彰.AIDS防治学.复旦大学出版社,2008:198-231. 被引量：1
  • 3Palella FJ, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunedefieieney virus infection. N Engl J Med, 1998, 338:853-860. 被引量：1
  • 4Granich RM, Gilks CF, Dye C, et al. Universal Voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet, 2009, 373:48-57. 被引量：1
  • 5Fujie Zhang. The effect of highly active anti-retroviral therapy on mortality in HIV-infected former plasma blood donors in China. Chn Infect Dis, 2008, 47:825-833. 被引量：1
  • 6Sulkowski S, Moore D, Mehta H, et al. Hepatitis C and progression of HIV disease. JAMA, 2002, 288:199-206. 被引量：1
  • 7Rockstroh JK, Mocroft A, Soriano V. Influence of hepatitis C virus Infection on HIV-1 Disease Progression and Respouse to Highly Active Antiretroviral Therapy. J Infect Dis, 2005, 192:992-1002. 被引量：1
  • 8Cameron DW, Japour AJ, Xu Y, et al. Ritonavir and Saquinavir Combination therapy for the treatment of HIV infection. AIDS, 1999,13:213-224. 被引量：1
  • 9Saves M, Vandentorren S, Daucourt V, et al. Severe hepatic cytolysis: incidence and risk factors in patients treated by antiretroviral combination Aquitaine cohort, France, 1996-1968. AIDS, 1999, 13 :F115-121. 被引量：1
  • 10Corbett EI, Watt CJ, Walker N, et al. The growing burden of tuberculosis: global trends and inferactions with HIV-epidemic. Arch Inter Med, 2003, 163:1009-1021. 被引量：1

引证文献2

二级引证文献12

中华检验医学杂志
2009年 第4期

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