摘要
目的观察高敏C反应蛋白(hsCRP)、可溶性细胞表面分化抗原40配体(sCD40L)、基质金属蛋白酶9(MMP-9)在急性脑缺血中的变化,探讨其在脑缺血早期诊断及防治中的意义。方法采用酶联免疫吸附测定法检测83例急性脑血栓形成(ACT)、40例短暂性脑缺血发作(TIA)患者及30例健康对照者血清hsCRPs、CD40L及MMP-9水平。结果ACT组和TIA组患者血清hsCRP、sCD40L和MMP-9均较健康对照组显著增加,hsCRP(458.2±13.4)μg/L(、433.5±21.1)μg/L vs(224.1±29.9)μg/L(P<0.01),sCD40L(7.8±1.3)kU/L、(7.0±1.2)kU/Lvs(4.2±1.1)kU/L(P<0.01),MMP-9(81.2±10.3)μg/L、(72.4±7.9)μg/L vs(33.9±6.7)μg/L(P<0.01);ACT组血清hsCRP、sCD40L和MMP-9均较TIA组患者显著增加(P<0.01)。结论sCD40L、MMP-9及hsCRP水平增高与粥样硬化斑块不稳定性、斑块破裂的发生有关,表明其可预测近期发生急性脑血栓形成的可能,抑制炎症反应可减轻病情。
Objective To investigate the changes of serum high-sensitivity C-reactive protein（hsCRP）, soluble CD40L （sCD40L）, and matrix metalloproteinase-9 （MMP-9） in the patients with acute cerebral ischemia （ACI）. Methods Enzyme-linked immunosorbent assay technique was used to detect serum hsCRP, sCD40L and MMP-9 levels in 30 healthy subjects,83 patients with acute cerebral thrombosis （ACT） and 40 patients with transient ischemic attack （TIA）. Results Serum hsCRP, sCD40L and MMP-9 showed higher levels in patients with ACT and TIA than in healthy control subjects, hsCRP （458.2±13.4）μg/L, （433.5±21.1） μg/L vs （224.1±29. 9）μg/L（ P〈0.01） sCD40L （7.8±1.3） kU/L, （7.0±1.2） kU/L vs （4. 2±1.1） kU/L（ P〈0.01）;MMP-9 （81.2±10. 3） μg/L, （72.4±7.9）μg/L vs （33.9±6.7）μg/L（ P〈0.01）. The levels of serum hsCRP,sCD40L and MMP-9 in patients with ACT were higher than in those with TIA（all P〈0.01）. Conclusion hsCRP, sCD40L and MMP-9 increases are associated with the instability and break of atherosclerotic plaques. The increase might be valuable markers for early diagnosis of acute cerebral thrombosis. The therapy of anti-inflammation may be a potential new method in the future.
出处
《临床荟萃》
CAS
2009年第8期672-674,共3页
Clinical Focus
基金
黑龙江省教育厅科技项目(10541111)
