摘要
目的:探讨组织因子凝血途径抑制物(TFPI)的变化在心脑血管病、各类肝病、肾病、白血病、糖尿病及系统性红斑性狼疮(SLE)中的临床意义。方法:测定上述各类疾病患者血浆中TFPI抗原(TFPI:Ag),采用双夹心FLISA抗原测定法。TFPI活性(TFPI:A)采用发色底物法。经统计学处理后作出客观评价。结果:心脑血管病(102例)、各类肝病(102例)、糖尿病(20例)及系统性红斑性狼疮(SLE,20例)患者血浆的TFPI水平增高,肝硬化失代偿期 TFPI:Ag降低,TFPI:A增高;慢性肾小球肾炎(尿毒症期,20例)的患者血浆TFPI:Ag与TFPI:A均增高;本组中10例经血透治疗后TFPI:Ag明显下降;急性非淋巴细胞白血病(20例,并发性性或亚急性DIC)TFPI:Ag与TFPI:A下降。上述结果经统计学处理均有显著意义。结论:炎症、肿瘤以及组织损害(特别是血管)患者TFPI的过度表达,治疗使疾病缓解后,可见其逐渐下降,但合并DIC时,血浆中TFPI的水平可降至正常或明显减低,可能是由于血栓形成,TFPI的消耗过多所致。肝功能受损致使其代偿失调时,TFPI在血浆中的水平降低。
Objective: To investigate the variation of TFPI level in patients with cardiovascular diseases, cere-brovascular diseases, hepatopathy, nephropathy, leukemia, diabetes or systemic lupus eiythomytous and its clinical significance. Method:The TFPI antigen level was detested by ELBA. Colouring substrate method was used to measure TFPI activity. The results were statistically processed and objectively evaluated. Result: Patients with cardiovascular diseases, hepatitis, diabetes or SLE had higher TFPI levels, while patients with de-compensated liver cirrhosis had lower TFPI antigen and higher TFPI activity. Both TFPI antigen and activity values increased in patients with chronic glomerulonephritis(uremia phase) and decreased in patients with acute non- lymphatic leukemia. (20 complicated with chronic or subacute DIC). 20 uremic patients had their TFPI antigen significantly lowered after hemodialysis.
出处
《血栓与止血学》
1998年第4期151-154,共4页
Chinese Journal of Thrombosis and Hemostasis
关键词
组织因子凝血途径抑制物
心脑血管病
肝病
肾病
白血病
糖尿病
系统性红斑性狼疮
Tissue Factor Pathway Inhibitor
Cardiovascular Disease
Ceiebrovascular Disease
Hepatopathy
Nephropathy
Leukemia Diabetes
Systemic Lupus Erythomytous
