摘要
骨髓微环境不仅支持正常造血细胞的生长和分化,而且有助于肿瘤细胞的生长,它在多发性骨髓瘤细胞的增生、分化、凋亡中起重要作用。多发性骨髓瘤(MM)的瘤细胞定居在骨髓很少浸润骨髓以外的器官,与肿瘤细胞所处的骨髓造血微环境密切相关。骨髓瘤细胞与骨髓基质细胞及细胞外基质相互黏附,并产生细胞因子,进而影响肿瘤细胞的存活,而且还影响瘤细胞对治疗的反应。MM是一个进展性、致死性疾病,传统的化疗很易发生耐药。目前随着免疫学、分子生物学的发展及对骨髓微环境的研究,一些新型的以生物学为基础的药物不仅针对瘤细胞本身,而且以骨髓微环境为靶子,通过改变骨髓微环境而达到克服耐药的目的,从而延长骨髓瘤患者的无病生存期。
Bone marrow microenvironment(BMM)not only support hematopoietic cells growth and dif- ferentiation,but also contribute to tumor cells growth.BMM play a critical role in proliferation,differentiation and apoptosis of multiple myeloma(MM)ceils.MM cells predominantly localize in bone marrow and rarely in- vade to other organs,which is closely associated with the bone marrow microenvironment.The MM cells ad- hero to extracetlular matrix proteins and BM stromal ceils,which affect the myleoma cells survial and the ther- aputic reaction through cell adhesion and cytokine-mediated mechanisms.Multiple myeloma is a aggressive and fatal disease.Conventional chemotherapy ultimately develop drug resistance.Nowadays,with the develop- ment of immunology and molecularbiology and approach to the bone marrow micrenviroment,Novel biological- ly-based drugs not only target to myeloma cell not only its BM milieu.These studies have also provided the framework for a new treatment paradigm that disruption of the bone marrow microenviroment overcome the drug resisence and prolong the patient disease-free survial in MM.
出处
《白血病．淋巴瘤》
CAS
2007年第4期317-320,共4页
Journal of Leukemia & Lymphoma
关键词
骨髓瘤
骨髓微环境
基质细胞
细胞因子
黏附
耐药
Multiple myeloma
Bone marrow microenvironment
Stromal cell
Cytokine
Adhesion
Drug resistence
