摘要
延缓慢性肾衰竭(CRF)的进展是CRF非透析治疗中的关键环节之一,有多种机制可加速CRF最终达到终末肾的进程。临床综合性阻断相关途径对延缓CRF进展有着重要作用,主要措施包括:低蛋白饮食,阻断肾素-血管紧张素系统,控制高血压、蛋白尿、高脂血症、高凝状态,抗肾脏纤维化和慢性低氧等。更多实验研究成果的临床应用正在期待中。
Delay of the progression is one of the key points in non-dialysic treatment of chronic renal failure. The multiplicity of mechanisms could accelerate the CRF progression to end-stage renal disease. Blocking those pathways play an important role in slowing the CRF progression and the measures include low protein diet, adrenal rennin-angiotensin system （RAS） blockade, control of hypertension and hyperlipidemia, reduction of proteinuria, treatment of anti-renal fibrosis and chronic hypoxia, and anti-coagulation, etc. More renoprotective agents are being moved from hypothesis to novel therapeutics.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2009年第4期310-313,325,共5页
Journal of Clinical Pediatrics
关键词
慢性肾衰竭
治疗
慢性进展
Key words： chronic renal failure
treatment
chronic progression
