摘要
目的:研究淫羊藿黄酮抗运动性疲劳作用的机制。方法:小鼠灌胃淫羊藿黄酮500,1500 mg.kg-1.d-1,qd,连续14 d后进行小鼠负重游泳试验,测定负重游泳时间、血清中肌酐、尿素氮和肝组织丙二醛(MDA)含量。另外考察不同浓度(0.4,1.0,2.0 g.L-1)的淫羊藿黄酮溶液体外对羟自由基(.OH)的清除作用。结果:淫羊藿黄酮能显著延长小鼠负重游泳时间;显著降低疲劳小鼠血清中肌酐和尿素氮含量;显著抑制小鼠肝组织MDA的产生,并在体外对羟自由基具有显著抑制作用。结论:淫羊藿黄酮具有明显的抗运动性疲劳作用,此作用与淫羊藿黄酮降低机体内自由基的功能相关。
Objective: To study the mechanism of resisting exercise fatigue by Epimedium flavones in mice. Methods: Epimedium flavones at 500 and 1 500 mg· kg^-1· d^-1 was orally administered once daily for 14 days in mice. After last dose, the time of loaded swimming was determined; the clearance of creatinine and urea nitrogen in serum and the concentration of malondialdehyde (MDA) were detected. The scavenging effect of Epimedium flavones at 0.4, 1.0 and 2.0 g·L^-1 on hydroxyl radicals ( ·OH) was observed in vitro. Results: Epimedium flavones significantly prolonged the time of loaded swimming; decreased the creatinine and urea nitrogen levels in serum; inhibited the MDA production in liver tissues of mice; and scavenged the hydroxyl radicals in vitro. Conclusion : Epimedium flavones can obviously promote the ability to resist exercise fatigue in mice ; the mechanism relates to elimination of hydroxyl radicals.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第6期553-555,559,共4页
Chinese Journal of New Drugs