摘要
口服液体控释给药系统是一种新型药物传递系统，因其存在物理不稳定性，所以能上市的品种较少。本文提出了解决物理稳定性的技术，如：选择具有水难溶性的药物；用药物饱和水溶液作为混悬介质；用非水溶液作为混悬介质；制成临用前重新配制的干混悬剂；优化混悬介质处方；采用定位（ｉｎｓｉｔｕ）凝胶机制；缓释乳剂；用离子交换树脂作为药物载体等。并着重介绍了口服药物脂液体控释系统的设计原理。
Oral liquid drug controlled release system(OLCRS) is a new drug delivery system .But only a few has been come into the market due to the physical instability.This article summarizes on the several possible approaches to solove the physical instability for OLCRS, such as:the selection of drugs insoluble in water, the saturated drug solution as a suspending medium,use of nonaqueous solvent,dry adsorbed emulsion reconstitutied before use,in situ gelling mechanisms sustainedrelease emulsion and ion exchange resins.The design principle of oral liquid drug controlled release system is emphasized.
出处
《药学进展》
CAS
1998年第1期9-15,共7页
Progress in Pharmaceutical Sciences
关键词
口服
液体控释
给药系统
缓释乳剂
缓释凝胶剂
Oral liquid drug controlled release system In situ gelling mechanisms Sustainedrelease dry emulsion Oral drug resinate liquid controlled release system Encapsulation
