摘要
目的采用喷雾干燥法制备右美沙芬的口服液体缓释制剂。方法以喷雾干燥法制备药物树脂缓释微粒,之后制成缓释混悬剂。并以高效液相法(HPLC)测定自制缓释混悬剂和市售品的含量和释放度,最后以相似因子法对2种制剂进行体外释药行为的评价。结果喷雾干燥法制备的缓释混悬剂,含量、释放度均符合市售品的质量标准,且体外释药行为与市售品无显著差异。结论喷雾干燥法也是一种制备口服液体缓释制剂的优良方法。
Objective To prepare oral liquid sustained release formulations of dextromethorphan. Methods Sustained release suspension is made after Preparing sustained release drug-resin particles by spray drying. To determine content and release of self-prepared and commercially available products by HPLC, estimate two agents in vitro release behavior by similarity factor method. Results The content and release of self-pre- pared product comply with the quality standards of commercially available product, and two agents have no sig- nificant differences in vitro release behavior. Conclusion It is an excellent method to prepare oral liquid sus- tained-release formulations by spray drying.
出处
《中国现代药物应用》
2010年第9期30-31,共2页
Chinese Journal of Modern Drug Application
