摘要
将４种稳定氮氧自由基引入５－氟尿嘧啶，合成了１０个新的５－氟尿嘧啶（Ｆｕ）自旋标记衍生物２ａ－８．经元素分析、ＩＲ、ＵＶ、ＭＳ和ＥＳＲ确定了其组成和结构．化合物对ＫＢ、ＨＣＴ－８和Ａ２７８０细胞毒性实验结果表明，化合物２ａ和３ａ的抗癌活性高于５－Ｆｕ，与ＨＣＦＵ的活性相当．
Ten new spin labeled derivatives of 5 fluorouracil(2a_8) were synthesized by introducing four kinds of stable nitroxyl radicals into N 1 and N 3 site of 5 Fu. The structures of these new compounds were confirmed by IR, UV, MS, ESR spectra and elemental analysis. The antitumor activities of these compounds were tested to be against KB, HCT 8 and A2780. The preliminary results showed that the antitumor activities of compounds 2a and 3a were stronger than that of 5 Fu and were similar to that of HCFU.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第3期395-398,共4页
Chemical Journal of Chinese Universities
