摘要
【目的】对绝经前女性子宫内膜癌患病危险因素进行研究。【方法】选择117例确诊为子宫内膜癌绝经前女性患者，按1：1比例收集117例同期体检正常女性，用单因素和多因素条件logistic回归分析探讨体重指数、吸烟史、饮酒史、糖尿痛和高血压病史、生育史、初潮年龄、初产年龄、流产史、HRT、口服避孕药史、肿瘤病史、肿瘤家族史等对绝经前女性子宫内膜癌的相对危险度。【结果】单因素分析体重指数，糖尿病和高血压、饮酒史、家族史、HRT、生育史、口服避孕药和流产史、初产年龄在两组间差异有显著性（P〈0．005）；logistic回归显示家族肿瘤史、HRT为绝经前女性子宫内膜癌患者的主要危险因子；而生育史、应用口服避孕药、初产年龄高、流产史为绝经前女性子宫内膜癌患者保护因素。【结论】家族肿瘤史、HRT为绝经前女性患子宫内膜癌的主要危险因素，对高危人群进行干预可能有助于早期防治子宫内膜癌。而生育史、应用口服避孕药、初产年龄高、流产史为绝经前女性子宫内膜癌患者保护因素。
[Objective]To study the risk factors of endometrial carcinoma before menopause. [Methods] The data from 117 patients with endometrial carcinoma before menopause and normal control （ n = 117） were analyzed by 1：1 matched case-control study. Risk factors were identified by univariate and logistic multivariate regression analysis. [Results] According to the univariate analysis, there were significant differences in body mass index, history of drinking, diabetes, hypertension, family history, HRT, childbearing history, history of oral contraceptive, primiparity age and miscarriage （ P 〈0.05）. By multivariate logistic regression analysis, tumor family history and HRT were conformed to be independent risk factors for endometrial carcinoma, while childbearing history, history of oral contraceptive, older primiparity age and miscarriage were protective factors in endometrial carcinoma. [Conclusion] Family history of tumor and HRT are independent risk factors in patients with endometrial carcinoma before menopause. More attention and proper life style control should be paid to such groups. Childbearing history, history of oral contraceptive, older primiparity age and miscar riage are protective factors in endometrial carcinoma.
出处
《医学临床研究》
CAS
2009年第3期482-483,486,共3页
Journal of Clinical Research
