摘要
目的检验芬兰、丹麦、泰国3个糖尿病危险评分量表在我国体检人群中的应用效力。方法对500名体检空腹血糖≥5.60mmol/L者采用3个量表分别对其进行评分,同时行口服葡萄糖耐量试验,计算各量表的灵敏度、特异度、正确诊断指数及ROC曲线下面积(AUC),以评价不同量表的效力。结果3个糖尿病危险评分量表的灵敏度、特异度均低于原人群;丹麦量表的筛检效力较理想,泰国量表的预测能力较高,芬兰量表的筛检与预测能力均一般。结论3个国外糖尿病危险评分量表应用于我国体检人群时,其筛查效力低于原人群,主要可能与不同人群的人口学特征差异有关,在推广应用时需对其进行效力检验。
Objective To evaluate the efficiency of Finnish, Dannish and Thai Diabetes Risk Scores for undiagnosed diabetes in Chi- nese health-checkup population. Methods A total of 500 health-checkup cases whose fasting plasma glucose （FPG）≥5.6 mmol/L were rated by using 3 Diabetes Risk Scores, followed by oral glucose tolerance tests （OGTT）. The sensitivity, specificity, Youden＇ index and the area under the receiver operating characteristic curve （AUC） for undiagnosed diabetes were calculated for the 3 screening risk scores. Results The sensitivities and the specificities of the 3 scores were substantially lower than originally de- scribed. The Dannish Diabetes Risk Score was ideal for screening, the Thai Risk Score for prediction, and the Finnish one had a poorer efficiency of screening and prediction. Conclusion The 3 foreign Diabetes Risk Scores yield low screening validity when ap- plied to Chinese health-checkup population, most likely due to differences in population characteristics. Therefore, the 3 scores should undergo validation tests before they are applied.
基金
2006年江苏省科技发展计划(社会发展)项目(BS2006073)
关键词
糖尿病
糖尿病危险评分
糖尿病危险评分量表
体检人群
diabetes mellitus
diabetes risk score
diabetes risk score scale
health-checkup population
