摘要
目的:急性胰腺炎(AP)的早期诊断较为困难,缺乏简便、敏感的实验室指标。文中探讨AP早期C反应蛋白(CRP)、血浆凝血功能检测对重症急性胰腺炎(SAP)的诊断价值。方法:72例AP患者早期检测CRP、凝血酶原时间(PT)、凝血酶原时间国际标准化指数(INR),部分活化凝血酶原时间(APTT)和纤维蛋白原浓度(FIB),进行CT平扫及增强扫描,CT严重指数(CTSI)评分。结果:SAP的CRP、PT、INR、APTT、FIB值及CTSI评分与轻症急性胰腺炎(MAP)比较均有显著性差异(P<0.01)。对CRP、CTSI评分、PT、INR、APTT、FIB各指标计算受试者工作特征曲线(ROC曲线)下面积(AUC),分别为0.890、0.855、0.927、0.996、0.959、0.966,与0.5相比均具有显著性差异(P<0.001)。结论:AP患者早期行CRP、凝血功能测定对SAP诊断有重要意义,INR是诊断价值最高的指标。
Objective：To study the diagnosis values in severe acute pancreatitis （SAP） by means of the detection of C-reactive protein （CRP） and coagulation function in the early period of acute pancreatitis （AP）. Methods：Seventy-two patients with AP accepted early detection of C-reactive protein （CRP）, prothrombin time （PT）, international normalized ratio （INR）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）, CT scan and enhanced CT, and the evaluation on the CT severity index （CTSI）. Results ：There were significant differences in the levels of CRP, PT, INR, APTT, FIB and the CTSI scores between severe AP （SAP） and mild AP （MAP） （P 〈0.01 ）. The areas under the Receiver Operating Characteristic Curve （AUC） on the calculation index of CRP, CTSI scores, PT, INR, APTT, FIB were 0. 890, 0. 855, 0. 927, 0. 996, 0. 959, 0. 966, and there were significant differences compared with 0.5 （ P 〈 0. 001 ）. Conclusions ： The detection of CRP and coagulation function in the early period of AP is of great significance in diagnosis in SAP, the INR is the best discriminating parameter.
出处
《医学研究生学报》
CAS
2009年第3期273-275,共3页
Journal of Medical Postgraduates
关键词
急性胰腺炎
C反应蛋白
凝血酶原时间
CT
受试者工作特征曲线
Acute panereatitis
C-reactive protein
Prothrombin time
X-rayed computed tomography
Receiver operating characteristic curve （ROC curve）
