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Ezrin和Ki67在乳腺导管内乳头状肿瘤鉴别诊断中的价值

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摘要 采用免疫组化技术检测Ezrin和Ki67在各类乳腺导管内乳头状肿瘤中的表达。结果:Ezrin和Ki67在乳腺导管内乳头状癌中的异常表达率分别为53.8%、73.1%,在非典型性乳头状瘤中分别为32.1%、42.9%,在良性乳头状瘤中分别为3.3%、20.0%,乳腺导管内乳头状癌中Ezrin和Ki67的异常表达率均明显高于良性和非典型性乳头状瘤。认为Ezrin可能参与了乳腺导管内乳头状肿瘤的癌变过程,Ki67可以反映其增殖程度和生物学行为,二者在各类乳腺导管内乳头状肿瘤的鉴别诊断中具有一定的参考价值。
作者 李节 张秋生
出处 《山东医药》 CAS 北大核心 2009年第8期86-87,共2页 Shandong Medical Journal
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