摘要
那氟沙星是日本大冢公司于20世纪80年代初研制开发的第三代喹诺酮类抗菌药。本品对革兰阳性菌、革兰阴性菌、厌氧菌和耐药菌等具有广谱抗菌活性,目前在临床上是以1%的软膏用于治疗痤疮等皮肤感染。本文比较系统地总结了那氟沙星的制备方法、药效学、毒理学、药动学和临床研究等方面的研究进展。
Nadifloxacin, developed in the early 1980s by Otsuka Pharmaceutical Co., Ltd., is a third generation of quinolone antibiotics which possesses broad-spectrum antibacterial activities against gram-positive and gram-negative bacteria, anaerobe and drug resistant bacteria etc. Current clinically used nadifloxacin in Japan is an ointment containing 1% nadifloxacin for the treatment of acne vulgaris and other dermatological infections. This review mainly summarized the preparation methods of nadifloxacin and its pharmacodynamics, toxicology, pharmacokinetics, as well as clinical studies.
出处
《国外医药（抗生素分册）》
CAS
2009年第2期68-75,共8页
World Notes on Antibiotics
关键词
那氟沙星
制备方法
药效学
毒理学
药动学
临床研究
nadifloxacin
preparation
pharmacodynamics
toxicology
pharmacokinetics
clinical studies
