摘要
目的合成那氟沙星(Nadifloxacin)并进行工艺优化。方法以8,9-二氟-5-甲基-6,7-二氢-1-氧代-1H,5H-苯并[i,j]喹嗪-2-甲酸为起始原料,经保护、缩合、水解等反应制得抗菌药那氟沙星。结果合成目标化合物,总收率为56.3%。结论本工艺反应条件平和,成本较低,收率较高。
AIM To synthesize nadifloxacin and improve the synthetic procedure. METHOD Nadifloxaein, an antibiotic, was synthesized through condensation, hydrolysis from 8,9-ditluoro-5-methyl-6,7-dlhydro- 1-oxo- 1 H, 5 H-benzo [ i, j ] quinolizine-2-earboxylic acid. RESULT Nadifloxacin was synthesized successfully and in a total yield of 56.3%. CONCLUSION This improved procedure is applicable to industry.
出处
《江苏药学与临床研究》
2006年第6期377-378,共2页
Jiangsu Pharmacertical and Clinical Research
关键词
那氟沙星
抗菌药
化学合成
Nadifloxacin
Antibiotic
Chemical synthesis