摘要
目的建立小鼠氟牙症分级标准。方法将雄性ICR小鼠48只随机分为4组,分别饮用含质量分数0、55、110和220mg/L氟化钠的双蒸水,实验为期42d。每天用数码相机记录并观察小鼠下切牙釉质的改变。偏振光下观察氟牙症小鼠下切牙釉质的矿化程度。结果小鼠切牙釉质发生了透明度、混浊、白色条纹、白垩色斑和缺损等不同程度的变化,偏振光下可见实验组釉质内不同程度的低密度褐色矿化不全区,小鼠氟牙症被分为11级。结论建立了小鼠氟牙症11级分级标准。
Objective To establish a graded standard of mice dental fluorosis. Methods 48 ICR mice were randomly divided into four groups and fed with double-distilled water containing 0, 55, 110 and 220 mg/L of sodium fluoride respectively for 42 days. The changes of the mandibular incisor enamel were recorded by digital camera everyday. The tooth mineralization was observed with a polarized light microscope. Results The fluorosed teeth enamel experienced changes in different degrees, such as transparency decline, white fine lines, scattered white spots or patches, white streaks, surface defects and so on. Different fuseescent pero-mineralization of low density could be discovered fi＇om adamatine layer in experiment groups by polarized light microscope. The changes of dental fluorosis are divided into 11 degrees. Conclusion The 11-degree graded standard of mice dental fluo- rosis was established.
出处
《国际口腔医学杂志》
CAS
2009年第2期140-143,共4页
International Journal of Stomatology
基金
西安市社会发展基金资助项目(SF200227)
关键词
氟化钠
氟牙症
分级标准
sodium fluoride
dental fluorosis
graded standard
