摘要
目的:探讨致药源性剥脱性皮炎高发的药物品种,寻求其预防和治疗方法。方法:回顾性调查1998～2008年中国知网中国期刊全文数据库收集的240例药源性剥脱性皮炎文献病例,并进行统计、分析。结果:药源性剥脱性皮炎男女发生比例为1.5∶1;主要以口服和静脉滴注为主;所涉及药品有19类133种,抗感染药、中枢神经系统药和抗痛风药排序列前3位,别嘌醇、卡马西平和苯巴比妥钠是引起剥脱性皮炎最多的3个药品;死亡病例15例,占6.25%;治疗方法仍以葡萄糖酸钙和抗组胺药配合下的大剂量皮质激素冲击疗法为主,须同时使用抗菌药物进行抗感染治疗,以减少继发败血症引起的死亡。结论:临床上应加强对重点药物的监测,以避免和减少抗感染药致剥脱性皮炎的发生。
OBJECTIVE： To probe into the drug categories causing high incidence of exfoliative dermatitis, and to explore the methods for the prevention and cure of this disease. METHODS： 240 exfoliative dermatitis cases publicly reported in domestic journal between 1998 and 2008 were reviewed retrospectively and analyzed statistically. RESULTS： Among the total 240 cases, 144 were male vs. 96 female, which was chiefly induced via oral and intravenous routes; a total of 19 drugs categories （133 kinds） were involved, dominating the first 3 places were anti- infective drugs, central nervous system drugs and antipodagric drugs. Allopurinol, carbamazepine and phenobarbital were top three drugs among all kinds of drugs inducing exfoliative dermatitis. 15 patients （6.25%） died. Exfoliative dermatitis was chiefly treated using stosstherapy in which a large dose of the eorticosteroids combined antihistamine drugs and calcium gluconate were used, meanwhile antibiotic drugs was used as an anti - infective therapy to reduce the death secondary to septicemia. CONCLUSION： It is urgent to tighten monitoring on the use of key drugs in clinical practice to avoid and decrease the incidence of exfoliative dermatitis induced by anti- infective drugs.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第8期614-616,共3页
China Pharmacy
关键词
剥脱性皮炎
药物过敏
文献分析
Exfoliative dermatitis
Drug allergy
Literature analysis
