摘要
目的:探讨适形放疗联合甲地孕酮治疗晚期胰腺癌的临床效果。方法:对照组15例晚期胰腺癌给予立体定向适形放疗,总处方剂量为55-65Gy。治疗组15例在对照组适形放疗的基础上给予甲地孕酮(160mg/d)口服;观察两组副反应发生率、消化道反应、以及生活质量情况。结果:治疗组血液学毒性和消化道反应发生率低于对照组(P<0.05);治疗组患者生活质量改善优于对照组(P<0.05);未见甲地孕酮所致的严重不良反应。结论:甲地孕酮对接受放疗的晚期胰腺癌患者在保护骨髓、减轻消化道反应和提高生活质量等方面具有明显作用。
Objective：To seek an effective treatment of stereotactic conformal radiotherapy and megestrilacetate（MA） for advanced pancreatic carcinoma.Methods： Fifteen patients were performed with stereotactic conformal radiotherapy in the control group.MA（160mg·d-1） was administered on the basis of the treatment in the control group for treatment group（15 cases）.Incidence of toxic and adverse reaction,digetive tract reaction and quality of life in patients of two groups were observed.Patients were treated by stereotactic conformal radiotherapy of 6MV-ray.Patients were fixed with vac-lok cushion of the device of stereotactic localization,the CT scanning results of 10 cases of advanced pancreatic carcinoma were put into the treatment planning system.According to the target area of tumor,sensitive organs and moving error drew GTV,CTV and PTV.The best plan was selected in considering the dose-volume histogram.Using 5-7 beams of non-coplanar radiation ray were choosed.PTV were surrounded by 90% isodose surves,radiation total dosage was 55-65Gy.Results： Rate of hematological toxicity and digestive tract reaction in the treatment group was lower than that in the control group（P〈0.05）.Quality of life was improved better in treatment group than that in the control group（P〈0.05）.Severe toxic and adverse effects induced by MA didn＇ t occur.Conclusion： MA has remarkable effects in protecting marrow,decreasing digestive tract reaction and improving the quality of life in the patients with advanced pancreatic carcinoma treated with stereotactic conformal radiotherapy.
出处
《现代肿瘤医学》
CAS
2009年第3期496-498,共3页
Journal of Modern Oncology
基金
黑龙江省教育厅课题(编号:11531198)
关键词
甲地孕酮
立体定向放射治疗
晚期胰腺癌
stereotactic conformal radiotherapy
megestrilacetate
advanced pancreatic carcinoma
