摘要
目的了解激光与鲜红斑痣病变皮肤的相互作用过程,确定不同波长辐照时血管中的能量分布模式。方法基于光子在分层组织模型中传输的蒙特卡罗模拟方法,建立以血管为主要研究对象的皮肤组织模型,探讨柱形血管截面上能量的分布规律。结果在光束传输方向上,能量分布按指数规律衰减,且在不同的横向位置上衰减曲线不同,从血管中心到边缘纵向上能量梯度趋于平坦;同一波长下,小直径血管截面上的能量分布比大直径血管均匀,532 nm激光在血管截面上产生的能量极大值大于595 nm激光,沿垂直组织表面方向的衰减程度也强于595 nm激光。595 nm激光在血管截面上的能量分布相对平坦。结论模拟表明鲜红斑痣组织模型中,血管目标在不同波长激光照射时具有不同的能量分布模式,组织内部的能量分布不仅与激光波长以及入射能量有关,也与组织的结构密切相关。
Objective Based on selective photothermolysis, to realize the interaction between laser and skin tissue when different wavelengths in- duced energy profile in vessel which conduced if the vessel could be coagulated. Methods Rooted in the Monte-Carlo algorithm for simulation photon transmitted in multi-layer tissue, constructed the model that was in the layered model embedded with columniform vessel, the energy profile on the vessel section was discussed. Results Along with the direction to which the beam transmitting, energy profile varied according to exponential curve. At different transverse position, the curves were not identified, and from the center of the vessel to both sides, energy gradients were gradually fiat. At the same wavelength, the energy profile on the small size vessel was much more flat than that on the bigger one. We found that 532 nm evoked higher maximal energy than 595 nm on the same size vessel section, and declined more rapidly along vertical direction. 595 nm Produced much more even distribution on the vessel section correspondingly. Conclusions The simulation reveals there are different energy profile modes in the same vessel when distinct wavelength injected, the energy distribution in the tissue is not only related to the laser wavelength or energy density, and it is also correlated with the skin structure.
出处
《中国激光医学杂志》
CAS
CSCD
2009年第1期16-22,64,65,共9页
Chinese Journal of Laser Medicine & Surgery
关键词
鲜红斑痣
激光
蒙特卡罗
模拟
Port-wine stain
Laser
Monte-Carlo
Mathematic modeling
Energy distribution
